Transplantable mouse OSCC cell lines derived from independent carcinogen-induced tumors.
Oral cavity squamous cell carcinoma (OSCC) is a prominent subset of head and neck cancers, which are the 6th most common cancer worldwide. The major risk factor for developing OSCC is carcinogen exposure, which distinguishes this subset of head and neck cancers from those induced by human papillomavirus. Despite advances in detection, surgery, chemotherapy, and radiation, the prognosis for OSCC has remained stable for decades. Furthermore, at the time of diagnosis, approximately two-thirds of OSCC patients have locoregionally advanced disease resulting in increased morbidity and mortality.
From the laboratory of Ravindra Uppaluri, MD, PhD, Washington University in Saint Louis.
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|Product Type:||Cell Line|
|Name:||Mouse Oral Squamous Cell Carcinoma (OSCC) Cell Lines|
|Cell Type:||Mouse oral cancer|
|Organism:||MOC1 and MOC22 were derived from primary tumors in C57BL/6 WT mice. MOC2 was derived from a chemokine receptor CXCR3 deficient mouse on a pure C57BL/6 background (of note, no major differences in the incidence of tumor formation were noted between the different genotypes).|
|Growth Conditions:||Suggested Protocol Kerafast also recommends following cell culture dishes/flasks manufacturer's instructions on cell seeding volume.|
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