This rabbit polyclonal antibody was generated against a cysteinylated antiproliferative factor (APF) backbone (TVPAAVVVAC) and recognizes APF backbone derivitives.
Antiproliferative factor (APF) is a low molecular weight, heat stable sialoglycopeptide that contains the transmembrane segment of Frizzled 8. It is made and secreted by bladder epithelial cells of patients with a condition known as interstitial cystitis (IC) which causes chronic pain due to ulcers, hemorrhaging, and thinning of the bladder epithelium. APF contributes to the pathology of IC by inhibiting bladder cell proliferation, and was also shown to regulate proliferation of bladder carcinoma cells. Recently, CKAP4/p63 was identified as a receptor for APF, but how its activity is mediated remains unknown.
From the laboratory of Susan K. Keay, MD, PhD, Department of Veteran Affairs.
|Molecular Weight:||929 Da|
|Immunogen:||KLH-conjugated 10 amino acid peptide|
|Species Immunized:||New Zealand White Rabbit|
|Purification Method:||Protein A|
|Method Used to Determine Concentration:||OD280|
|Buffer:||PBS pH 7.4 with 0.1% sodium azide|
|Tested Applications:||APF bioassay/dot blot|
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