These murine monoclonal antibodies recognize β2-glycoprotein I.
β2-glycoprotein I is a phospholipid-binding protein found in the blood and is known to bind to anionic phospholipids. Antibodies to β2-glycoprotein I are considered to be a subset of a larger group of antibodies called "anti-phospholipid antibodies". Anti-phospholipid antibodies recognize phospholipid-binding proteins (like β2-glycoprotein I), rather than phospholipids directly, and are clinically relevant antibodies in a clinical syndrome called "anti-phospholipid syndrome" (APS) and in systemic lupus erythematosus (SLE). They are associated with thrombotic events and pregnancy morbidity in these patients. Thus, our monoclonal anti-β2-glycoprotein I antibodies could be useful as positive controls in clinical assays that measure these antibodies (i.e., "anti-cardiolipin assays" [which detect antibodies that recognize bovine β2-glycoprotein I that is bound to cardiolipin] and "anti-β2-glycoprotein I assays" [which detect antibodies that recognize human β2-glycoprotein I].
From the laboratory of Joyce Rauch, PhD, McGill University.
|Purification Method:||Protein G|
|Buffer:||0.1M Sodium Phosphate, pH 7.4, 0.15M NaCl, 0.05% (w/v) Sodium Azide|
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