These mouse antibodies incorporate the variable regions of broadly flavivirus cross-reactive mAb 6B6C-1 (specific for the flaviviral envelope (E) protein) into a plasmid construct containing the human IgG γ1 chain. The antibodies recognize Flavivirus (6B6C-1).
The flavivirus inlcudes West Nile virus, dengue virus, tick-borne encephalitis virus, yellow fever virus, Zika virus and several other viruses which may cause encephalitis. Flaviviruses have a (+) sense RNA genome and replicate in the cytoplasm of the host cells. The genome mimics the cellular mRNA molecule in all aspects except for the absence of the poly-adenylated (poly-A) tail. This feature allows the virus to exploit cellular apparatus to synthesise both structural and non-structural proteins, during replication.
From the laboratory of Centers for Disease Control and Prevention.
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|Antigen:||Flaviviral envelope (E) protein|
6GF4: pdHL2-6G, VH and VK regions of mMAb 6B6C-1 was incorporated separately into the human IgG expression construct pdHL2 generating plasmid pdHL2-6G (6B6C-1:IgG)
6ME2: The VH and VK regions of 6B6C-1 were incorporated into the human IgM expression construct pJH2 by ligation, generating plasmid pJH-6M (6B6C-1:IgM)
|Species Immunized:||None; Sp2/0-Ag14 (Sp2) murine myeloma cells|
|Buffer:||Cell Culture Supernatant|