These IgG2 mouse monoclonal idiotypic antibodies were produced against ME361 and are specific for human ganglioside GD2.
Anti-idiotypic antibodies are antibodies that can be elicited against the variable region of other antibody molecules. GM2 and GD2 gangliosides are sialic acid-containing glycosphingolipids. GalNAc-T is the enzyme involved in the biosynthesis of G(M2) and G(D2) glycosphingolipids. GalNAc-T catalyzes the transfer of GalNAc into G(M3) and G(D3) by a beta-1,4 linkage, resulting in the synthesis of G(M2) and G(D2), respectively. Three transcript variants encoding different isoforms have been found for this gene. Gangliosides are a class of carbohydrate-rich glycolipids of extremely large size and complexity, which are usually found on the outer surface of cell membranes, especially among the cells of the nervous system. GD2 is present in central nervous tissue, in melanomas, gliomas, neuroblastoma, and small cell lung carcinoma at high density. In general, ganglioside antigen GD2 occurs in primary and metastic melanoma and is less abundantly present in normal tissue.
From the laboratory of Dorothee Herlyn, DVM, The Wistar Institute.
|Antigen:||Anti-idiotypic, mimic GD2 function|
|Purification Method:||Protein G|
|Buffer:||PBS, 0.05% (w/v) Sodium Azide|
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