Anti-MAGE-A11 Antibodies
These rabbit IgG polyclonal antibodies were raised against purified FLAG-Melanoma-associated antigen 11 (MAGE-A11) protein expressed from
baculovirus and recognize human MAGE-A11.
Highlights:
- Recognize human MAGE-A11
- Suitable for Western Blot applications
MAGE-A11 acts as androgen receptor coregulator that increases androgen receptor activity by modulating the receptors interdomain interaction. May play a role in embryonal development and tumor transformation or aspects of tumor progression.
From the laboratory of Elizabeth M. Wilson, PhD
, University of North Carolina at Chapel Hill.
These rabbit IgG polyclonal antibodies were raised against purified FLAG-Melanoma-associated antigen 11 (MAGE-A11) protein expressed from baculovirus and recognize human MAGE-A11.
Highlights:
- Recognize human MAGE-A11
- Suitable for Western Blot applications
MAGE-A11 acts as androgen receptor coregulator that increases androgen receptor activity by modulating the receptors interdomain interaction. May play a role in embryonal development and tumor transformation or aspects of tumor progression.
From the laboratory of Elizabeth M. Wilson, PhD , University of North Carolina at Chapel Hill.
| Catalog Number | Product | DataSheet | Size | AVAILABILITY | Price | Qty |
|---|
Specifications
| Product Type: | Antibody |
| Antigen: | MAGE-A11 |
| Accession ID: | P43364, NP-005357, NP_005357.2 |
| Molecular Weight: | Calculated mol wt = 47,998 Da, SDS gel migration = ~58 kDa |
| Isotype: | IgG |
| Clonality: | Polyclonal |
| Clone Name: | MAGE-A11-1 rabbit 100, MAGE-A11-2 rabbit 20494 |
| Reactivity: | Human |
| Immunogen: | Purified FLAG-MAGE-A11 protein expressed from baculovirus |
| Species Immunized: | Rabbit |
| Purification Method: | Unpurified serum. Pierce Melon column recommended for further purification. |
| Buffer: | Serum |
| Tested Applications: | WB (0.1 µg/ml for ectopic MAGE-A11 expression to 10 µg/ml for endogenous MAGE-A11) |
| Comments: | MAGE-A11-1 antibody also reacts with FLAG tag , MAGE-A11-2 antibody does not react with FLAG tag |
| Storage: | -80C |
| Shipped: | Cold Packs (Domestic, Overnight); Dry Ice (International) |
Provider
From the laboratory of Elizabeth M. Wilson, PhD, University of North Carolina at Chapel Hill.
References
- Askew EB, Bai S, Hnat AT, Minges JT, Wilson EM 2009 Melanoma antigen gene protein-A11 (MAGE-11) F-box links the androgen receptor NH2-terminal transactivation domain to p160 coactivators. J Biol Chem 284:34793-34808.
- Askew EB, Bai S, Blackwelder AJ, Wilson EM 2010 Transcriptional synergy between melanoma antigen gene protein-A11 (MAGE-11) and p300 in androgen receptor signaling. J Biol Chem 285:21824-21836.
- Su S, Blackwelder AJ, Grossman G, Minges JT, Yuan L, Young SL, Wilson EM 2012 Primate-specific melanoma antigen-A11 regulates isoform-specific human progesterone receptor-B transactivation. J Biol Chem 287:34809-34824.
- Minges JT, Su S, Grossman G, Blackwelder AJ, Pop EA, Mohler JL, Wilson EM 2013 Melanoma antigen-A11 (MAGE-A11) enhances transcriptional activity by linking androgen receptor dimers. J Biol Chem 288:1939-1952.
- Su S, Minges JT, Grossman G, Blackwelder AJ, Mohler JL, Wilson EM 2013 Proto-oncogene activity of melanoma antigen-A11 (MAGE-A11) regulates retinoblastoma-related p107 and E2F1 proteins. J Biol Chem 288:24809-24824.
- Minges JT, Grossman G, Zhang P, Kafri T, Wilson EM 2015 Post-translational down-regulation of melanoma antigen-A11 (MAGE-A11) by human p14-ARF tumor suppressor. J Biol Chem 290:25174-25187.
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