Anti-Osteopontin (SPP1), mouse [LF-175] Antibody

This rabbit IgG polyclonal antibody was generated against peptide and specific for mouse Osteopontin (SPP1).

Highlights:

  • Recognizes mouse SPP1
  • Suitable for Immunohistochemistry and Western Blot applications

Osteopontin is a phosphoglycoprotein synthesized in a variety of tissues and cells. It was originally identified as a bone matrix protein and subsequently as a cytokine produced by various immune and transformed cell lines. OPN is a biomarker for various types of cancers and inflammatory diseases. Excessive or dysregulated OPN expression has been linked to the pathogenesis of both autoimmune disorders such as multiple sclerosis, systemic lupus erythematosus, rheumatoid arthritis, atherosclerosis and other inflammatory diseases including cardiovascular disease, chronic obstructive pulmonary disease, inflammatory bowel disease, liver disease and asthma.

From the laboratory of Larry W. Fisher, PhD, National Institute of Dental and Craniofacial Research/NIH.

Catalog Number Product DataSheet Size AVAILABILITY Price Qty
ENH094-FP
Anti-Osteopontin (SPP1), mouse [LF-175] Antibody, 100uL
100uL In stock
Regular Price:$306.00
On Sale:

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Specifications

Product Type: Antibody
Antigen: Osteopontin (SPP1), human
Accession ID: P10451.1
Molecular Weight: 32459 Da
Clonality: Polyclonal
Clone Name: LF-175
Reactivity: Mouse
Immunogen: Recombinant E. coli
Species Immunized: Rabbit
Epitope: YESENGEPRGDNYRAYED
Buffer: Whole serum
Tested Applications: WB 1:2000, IHC 1:300
Storage: -80C
Shipped: Dry Ice

Provider
From the laboratory of Larry W. Fisher, PhD, National Institute of Dental and Craniofacial Research.
References
  1. Foster BL.Methods for studying tooth root cementum by light microscopy. Int J Oral Sci. 2012 Sep;4(3):119-28.
  2. Foster BL, Sheen CR, Hatch NE, Liu J, Cory E, Narisawa S, Kiffer-Moreira T, Sah RL, Whyte MP, Somerman MJ, Millán JL. Periodontal Defects in the A116T Knock-in Murine Model of Odontohypophosphatasia. J Dent Res. 2015 May;94(5):706-14.
  3. Lim WH, Liu B, Hunter DJ, Cheng D, Mah SJ, Helms JA. Downregulation of Wnt causes root resorption. Am J Orthod Dentofacial Orthop. 2014 Sep;146(3):337-45.
  4. Cheng SL, Shin CS, Towler DA, Civitelli R. A dominant negative cadherin inhibits osteoblast differentiation. J Bone Miner Res. 2000 Dec;15(12):2362-70.
  5. Uaesoontrachoon K, Wasgewatte Wijesinghe DK, Mackie EJ, Pagel CN. Osteopontin deficiency delays inflammatory infiltration and the onset of muscle regeneration in a mouse model of muscle injury. Dis Model Mech. 2013 Jan;6(1):197-205.
  6. Addison WN, Azari F, Sørensen ES, Kaartinen MT, McKee MD. Pyrophosphate inhibits mineralization of osteoblast cultures by binding to mineral, up-regulating osteopontin, and inhibiting alkaline phosphatase activity. J Biol Chem. 2007 May 25;282(21):15872-83.
  7. Foster BL, Nagatomo KJ, Nociti FH Jr, Fong H, Dunn D, Tran AB, Wang W, Narisawa S, Millán JL, Somerman MJ. A pre-clinical murine model of oral implant osseointegration. Central role of pyrophosphate in acellular cementum formation. PLoS One. 2012;7(6):e38393.
  8. Ogbureke KU, Fisher LW. Renal expression of SIBLING proteins and their partner matrix metalloproteinases (MMPs). Kidney Int. 2005 Jul;68(1):155-66.
  9. Salmon B, Bardet C, Coyac BR, Baroukh B, Naji J, Rowe PS, Opsahl Vital S, Linglart A, Mckee MD, Chaussain C. Abnormal osteopontin and matrix extracellular phosphoglycoprotein localization, and odontoblast differentiation, in X-linked hypophosphatemic teeth. Connect Tissue Res. 2014 Aug;55 Suppl 1:79-82.

If you publish research with this product, please let us know so we can cite your paper.

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