CB1 Cannabinoid Receptor Expressing HEK293 Cell Lines
Human, mouse or rat cannabinoid receptor type 1 (CB1) expressing HEK293 cells.
Cannabinoid receptors are located throughout the body and are part of the endocannabinoid system. A major function of CB1 cannabinoid receptors expressed on neurons is to inhibit neurotransmission, often through a retrograde signaling system. CB1 receptors are involved in a variety of physiological processes including regulation of appetite, pain-sensation, mood, and memory. While CB1 cannabinoid receptors are one of the most abundant G protein-coupled receptors in the brain, they also found in many non-neuronal tissues including the liver, adipocytes, and some immune cells.
From the laboratory of Ken Mackie, MD, Indiana University.
Human, mouse or rat cannabinoid receptor type 1 (CB1) expressing HEK293 cells.
Cannabinoid receptors are located throughout the body and are part of the endocannabinoid system. A major function of CB1 cannabinoid receptors expressed on neurons is to inhibit neurotransmission, often through a retrograde signaling system. CB1 receptors are involved in a variety of physiological processes including regulation of appetite, pain-sensation, mood, and memory. While CB1 cannabinoid receptors are one of the most abundant G protein-coupled receptors in the brain, they also found in many non-neuronal tissues including the liver, adipocytes, and some immune cells.
From the laboratory of Ken Mackie, MD, Indiana University.
| Catalog Number | Product | DataSheet | Size | AVAILABILITY | Price | Qty |
|---|
| Product Type: | Cell Line |
| Cell Type: | HEK293 |
| Accession ID: | P21554 |
| Organism: | Human, mouse or rat |
| Source: | Embryonic Kidney |
| Morphology: | Epithelial |
| Biosafety Level: | BSL-2 |
| Growth Conditions: |
DMEM, 10% FBS, (1mg/mL) G418, Pen/Strep (See  Suggested Protocol for details)
|
| Subculturing: | 0.05% Trypsin-EDTA/Versene |
| Cryopreservation: | 90% FBS, 10% DMSO |
| Comments: | CB1 receptor has a N-terminus HA tag |
| Storage: | Liquid nitrogen |
| Shipped: | Dry Ice |
- Daigle TL, Kearn CS, Mackie K. Rapid CB1 cannabinoid receptor desensitization defines the time course of ERK1/2 MAP kinase signaling. Neuropharmacology. 2008 Jan;54(1):36-44.
- Roger C, Buch C, Muller T, et al. Simultaneous Inhibition of Peripheral CB1R and iNOS Mitigates Obesity-Related Dyslipidemia Through Distinct Mechanisms [published online ahead of print, 2020 Jul 17]. Diabetes. 2020;db200078. View article
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