Rat Task Expressing CHO Cell Lines
Immortalized cell lines that stably overexpresses rat potassium channel subfamily K member 1 and/or 3 (TASK-1 and TASK-3) channel subunits K2P3 and K2P9, Kcnk3 and Kcnk9.
Highlights:
- Ideal for studying the channel properties
- Useful in cell-based assays for screening channel modulators
- Study the properties of the heterodimeric TASK-1-TASK-3 channel
Potassium channel subfamily K members TASK 1 and 3 members of the two-pore-domain channel family, are widely expressed leak potassium channels responsible for maintenance of cell membrane potential and input resistance. They act as an outward rectifier when external potassium concentration is low and when external potassium concentration is high, current is inward.
From the laboratory of Douglas A. Bayliss, PhD, University of Virginia.
Immortalized cell lines that stably overexpresses rat potassium channel subfamily K member 1 and/or 3 (TASK-1 and TASK-3) channel subunits K2P3 and K2P9, Kcnk3 and Kcnk9.
Highlights:
- Ideal for studying the channel properties
- Useful in cell-based assays for screening channel modulators
- Study the properties of the heterodimeric TASK-1-TASK-3 channel
Potassium channel subfamily K members TASK 1 and 3 members of the two-pore-domain channel family, are widely expressed leak potassium channels responsible for maintenance of cell membrane potential and input resistance. They act as an outward rectifier when external potassium concentration is low and when external potassium concentration is high, current is inward.
From the laboratory of Douglas A. Bayliss, PhD, University of Virginia.
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| Product Type: | Cell Line |
| Name: | Rat Task-1 (Kcnk3) Expressing CHO Cell Line; Rat Task-3 (Kcnk9) Expressing CHO Cell Line; Rat Task-1/Task-3 (Kcnk3/Kcnk9) Expressing CHO Cell Line |
| Cell Type: | CHO (Chinese hamster ovary) cells |
| Accession ID: | O14649, Q9NPC2, Kcnk3, CVCL_HC54; Kcnk9, CVCL_HC56; Kcnk3/Kcnk9, CVCL_HC55 |
| Organism: | Rat |
| Growth Conditions: | Hams/F12 with 15% FBS and penn/strep. Maintain under selection with hygromycin (400 ug/ml) and blasticidin (10ug/ml); induce O/N with 0.5ug/ml tetracycline |
| Storage: | Liquid nitrogen |
| Shipped: | Dry ice |
- Talley EM, Bayliss DA. Modulation of TASK-1 (Kcnk3) and TASK-3 (Kcnk9) potassium channels: volatile anesthetics and neurotransmitters share a molecular site of action. J Biol Chem. 2002 May 17;277(20):17733-42.
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