Rat Task Expressing CHO Cell Lines

Immortalized cell lines that stably overexpresses rat potassium channel subfamily K member 1 and/or 3 (TASK-1 and TASK-3) channel subunits K2P3 and K2P9, Kcnk3 and Kcnk9.

Highlights:

  • Ideal for studying the channel properties
  • Useful in cell-based assays for screening channel modulators
  • Study the properties of the heterodimeric TASK-1-TASK-3 channel

Potassium channel subfamily K members TASK 1 and 3 members of the two-pore-domain channel family, are widely expressed leak potassium channels responsible for maintenance of cell membrane potential and input resistance. They act as an outward rectifier when external potassium concentration is low and when external potassium concentration is high, current is inward.

From the laboratory of Douglas A. Bayliss, PhD, University of Virginia.

Catalog Number Product Size AVAILABILITY Price Qty
EG0003-FP
Rat Task-1 (Kcnk3) Expressing CHO Cell Line
1 vial 3-5 weeks
Regular Price:$599.00
EG0004-FP
Rat Task-3 (Kcnk9) Expressing CHO Cell Line
1 vial 3-5 weeks
Regular Price:$599.00
EG0005-FP
Rat Task-1/Task-3 (Kcnk3/Kcnk9) Expressing CHO Cell Line
1 vial 3-5 weeks
Regular Price:$599.00

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Specifications

Product Type: Cell Line
Name: Rat Task-1 (Kcnk3) Expressing CHO Cell Line; Rat Task-3 (Kcnk9) Expressing CHO Cell Line; Rat Task-1/Task-3 (Kcnk3/Kcnk9) Expressing CHO Cell Line
Cell Type: CHO (Chinese hamster ovary) cells
Organism: Rat
Accession ID: Kcnk3, CVCL_HC54; Kcnk9, CVCL_HC56; Kcnk3/Kcnk9, CVCL_HC55
Growth Conditions: Hams/F12 with 15% FBS and penn/strep. Maintain under selection with hygromycin (400 ug/ml) and blasticidin (10ug/ml); induce O/N with 0.5ug/ml tetracycline
Storage: Liquid nitrogen
Shipped: Dry ice

Provider
From the laboratory of Douglas A. Bayliss, PhD, University of Virginia.
References
  1. Talley EM, Bayliss DA. Modulation of TASK-1 (Kcnk3) and TASK-3 (Kcnk9) potassium channels: volatile anesthetics and neurotransmitters share a molecular site of action. J Biol Chem. 2002 May 17;277(20):17733-42.

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