Methyltetrazine-activated TAMRA dye reacts with TCO-containing compounds via a Inverse-Electron-Demand Diels-Alder reaction to form a stable covalent bond and does not require Cu-catalyst or elevated temperatures.
Tetrazine/TCOs are heterobifunctional reagents used for converting azido-containing peptides or protein into tetrazine-modified peptides or protein without the need for catalyst or axillary reagents. The inverse-electron demand Diels-Alder cycloaddition reaction of TCO with tetrazines is a bioorthogonal reaction that possesses exceptional kinetics (k > 800 -1s-1) and selectivity. Such excellent reaction rate constants are unparalleled by any other bioorthogonal reaction pair described to date.
|Product Type:||Small Molecule|
|Format:||Red amorphous solid|
|Solubility:||Water, DMSO, DMF, MeOH|
|Spectral Information:||Abs/Em = 553/575 nm|
|Storage:||Upon receipt store at -20C|
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