Methyltetrazine-NHS Ester

Methyltetrazine-NHS Ester is an amine-reactive building block used for modification of amine-containing molecule in organic media. It reacts with primary amines (e.g., side chain of lysine residues or aminosilane-coated surfaces) at neutral or slightly basic pH to form covalent bonds. Short spacer arm adds minimal mass to modified molecules (230.2 daltons).

Tetrazine/TCOs are heterobifunctional reagents used for converting azido-containing peptides or protein into tetrazine-modified peptides or protein without the need for catalyst or axillary reagents. The inverse-electron demand Diels-Alder cycloaddition reaction of TCO with tetrazines is a bioorthogonal reaction that possesses exceptional kinetics (k > 800 -1s-1) and selectivity. Such excellent reaction rate constants are unparalleled by any other bioorthogonal reaction pair described to date.

Catalog Number Product DataSheet Size AVAILABILITY Price Qty
Methyltetrazine-NHS Ester, 25 mg
25mg In stock
Regular Price:$153.00
On Sale:
Methyltetrazine-NHS Ester, 100 mg
100mg In stock
Regular Price:$293.00
On Sale:
Methyltetrazine-NHS Ester, 500 mg
500mg In stock
Regular Price:$734.00
On Sale:
Methyltetrazine-NHS Ester, 1 G
1 G In stock
Regular Price:$1,380.00
On Sale:

Product Type: Small Molecule
Chemical Formula: C15H13N5O4
CAS number: 1644644-96-1
Molecular Weight: 327.29
Variant MPN: 1128
Format: Red crystalline
Purity: >95% (HPLC)
Solubility: DMSO, DMF
Storage: -20C. Desiccate
Shipped: Ambient


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