This lentivirus expresses BRN2 under the control of the Tet promoter.
BRN2 (also known as POU3F2) encodes a member of the POU-III class of neural transcription factors. The encoded protein is involved in neuronal differentiation and enhances the activation of corticotropin-releasing hormone regulated genes. Overexpression of this protein is associated with an increase in the proliferation of melanoma cells.
|Vector Information:||Vector includes both 5? and 3? lentiviral LTR and all necessary elements for effective transduction; woodchuck hepatitis virus posttranscriptional regulatory element (WPRE)|
|Target Gene / Reporter(s):||Brn2|
|Titer:||1 x 10^8TU/mL|
|Storage:||Store at -80C. Multiple freeze/thaw cycles not recommended.|
NOTE: This Inducible Tet-On lentivirus does not contain the reverse tetracycline-controlled transactivator (rtTA) protein, which is required for the Tet-On system. Unless the cells used stably produce rtTA, it is necessary to cotransduce this lentivirus with a rtTA lentivirus (rtTA (CMV, neomycin) Lentivirus or rtTA (CMV, puromycin) Lentivirus.
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