Anti-Rabies Virus Glycoprotein Antibodies
These mouse IgG monoclonal antibodies were generated against virus and are specific for the glycoprotein of rabies virus.
Rabies is a viral disease that causes acute inflammation of the brain in humans and other warm-blooded animals. The rabies virus glycoprotein attaches the virus to a host cellular receptor, inducing endocytosis of the virion. In the endosome, the acidic pH induces conformational changes in the glycoprotein trimer, which trigger fusion between virus and cell membrane. There is convincing in vitro evidence that the muscular form of the nicotinic acetylcholine receptor (nAChR), the neuronal cell adhesion molecule (NCAM), and the p75 neurotrophin receptor (p75NTR) bind glycoprotein and thereby facilitate rabies virus entry into cells.
From the laboratory of Tadeusz J. Wiktor, DVM, The Wistar Institute.
These mouse IgG monoclonal antibodies were generated against virus and are specific for the glycoprotein of rabies virus.
Rabies is a viral disease that causes acute inflammation of the brain in humans and other warm-blooded animals. The rabies virus glycoprotein attaches the virus to a host cellular receptor, inducing endocytosis of the virion. In the endosome, the acidic pH induces conformational changes in the glycoprotein trimer, which trigger fusion between virus and cell membrane. There is convincing in vitro evidence that the muscular form of the nicotinic acetylcholine receptor (nAChR), the neuronal cell adhesion molecule (NCAM), and the p75 neurotrophin receptor (p75NTR) bind glycoprotein and thereby facilitate rabies virus entry into cells.
From the laboratory of Tadeusz J. Wiktor, DVM, The Wistar Institute.
| Catalog Number | Product | DataSheet | Size | AVAILABILITY | Price | Qty |
|---|
| Product Type: | Antibody |
| Antigen: | Rabies capsid glycoprotein |
| Accession ID: | P03524 |
| Isotype: | IgG |
| Clonality: | Monoclonal |
| Clone Name: | 1105-3 |
| Reactivity: | Rabies virus |
| Immunogen: | Virus |
| Species Immunized: | Mouse |
| Purification Method: | Protein G |
| Buffer: | 0.1M Sodium Phosphate, pH 7.4, 0.15M NaCl, 0.05% (w/v) Sodium Azide |
| Tested Applications: | IF, Virus neutralization and binding assays. Neutrilizes a wide variety of Rabies viruses from dog, bat, human isolates (Dietzschold, et al, Wiktor, Koprowski,Rev. Inf. Dis, 1988) |
| Storage: | -20C |
| Shipped: | Cold packs |
Anti-Rabies Virus Glycoprotein Antibodies
| Clone Name: | 1105-3 | 1103-4 | 504-1 |
| Antigen Name: | Rabies capsid glycoprotein | Rabies capsid glycoprotein | Rabies capsid glycoprotein |
| Immunogen Isotype: | IgG | - | IgG |
| Clonality: | Monoclonal | Monoclonal | Monoclonal |
| Species Reactivity: | Rabies virus | Rabies virus | Rabies virus |
| Recognized Strains: | Neutrilizes a wide variety of Rabies viruses from dog, bat, human isolates (Dietzschold, et al, Wiktor, Koprowski,Rev. Inf. Dis, 1988) | Recognizes and neutralizes ERA, Kelev, CVS-11 and HEP rabies viruses (Wunner et al, 1988.) Does not neutralize Nigerian street Rabies strains (Ogunkoya, Beran and Wiktor, 2006 ) | Recognizes CVS Rabies strain. DOES NOT neutralize Nigerian strains (Ogunkoya, Beran and Wiktor, 2006 ) or bat, dog or human strains of various origin |
| Species Immunized: | Mouse | Mouse | Mouse |
| Immunogen: | Virus | Virus | Virus |
| Purification Method: | Protein G | Protein G | Protein G |
| Storage Buffer: | 0.1M Sodium Phosphate, pH 7.4, 0.15M NaCl, 0.05% (w/v) Sodium Azide | ||
| Tested Applications: | IF, Virus neutralization and binding assays | IF, Virus neutralization and binding assays | IF, Virus neutralization and binding assays |
| Storage Temperature: | -20C | -20C | -20C |
| Shipped: | Cold packs | Cold packs | Cold packs |
- Dietzschold B, Rupprecht CE, Tollis M, Lafon M, Mattei J, Wiktor TJ, Koprowski H. Antigenic diversity of the glycoprotein and nucleocapsid proteins of rabies and rabies-related viruses: implications for epidemiology and control of rabies. Rev Infect Dis. 1988 Nov-Dec;10 Suppl 4:S785-98.
- Ogunkoya AB, Beran GW, Wiktor TJ. Antigenic analysis of some Nigerian street rabies virus using monoclonal antibodies. Nigerian Veterinary Journal Vol. 27 (2) 2006: pp. 41-53.
- Wunner WH, Larson JK, Dietzschold B, Smith CL. The molecular biology of rabies viruses. Rev Infect Dis. 1988 Nov-Dec;10 Suppl 4:S771-84.
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