A TCO-activated Cy5 dye for chemoselective labeling and detection of TCO-tagged molecules.
A TCO-activated Cy5 probe can be used for detection and visualization of tetrazine-containing molecules. TCO moiety reacts with tetrazines to produce a stable, covalent linkage, also referred to as the inverse-electron demand Diels-Alder cycloaddition reaction. This reaction is extremely fast (k > 800 M-1s-1), selective, and biocompatible. Such excellent reaction rate constants are unparalleled by any other bioorthogonal reaction pair described to date.
|Product Type:||Small Molecule|
|Molecular Weight:||943.16 (protonated)|
|Extinction Coefficient:||251000 M-1cm-1|
|Solubility:||Water, DMSO, DMF, MeOH|
|Spectral Information:||Abs/Em = 647/663 nm|
|Comments:||CF280: 0.05; CF260: 0.05|
|Storage:||Upon receipt store at -20C|
1. Lueckgen A, Garske DS, Ellinghaus A, Mooney DJ, Duda GN, Cipitria A. Dual alginate crosslinking for local patterning of biophysical and biochemical properties [published online ahead of print, 2020 Jul 28]. Acta Biomater. 2020;S1742-7061(20)30433-5. View article
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