Cy5 - TCO

A TCO-activated Cy5 dye for chemoselective labeling and detection of TCO-tagged molecules.

A TCO-activated Cy5 probe can be used for detection and visualization of tetrazine-containing molecules. TCO moiety reacts with tetrazines to produce a stable, covalent linkage, also referred to as the inverse-electron demand Diels-Alder cycloaddition reaction. This reaction is extremely fast (k > 800 M-1s-1), selective, and biocompatible. Such excellent reaction rate constants are unparalleled by any other bioorthogonal reaction pair described to date.

Catalog Number Product DataSheet Size AVAILABILITY Price Qty
Cy5-TCO, 1 mg
1mg In stock
Regular Price:$182.00
On Sale:
Cy5-TCO, 5 mg
5mg In stock
Regular Price:$613.00
On Sale:
Cy5-TCO, 25 mg
25mg In stock
Regular Price:$1,907.00
On Sale:

Product Type: Small Molecule
Name: Cy5-TCO
Chemical Formula: C45H60N4O12S3(protonated)
Molecular Weight: 943.16 (protonated)
Extinction Coefficient: 251000 M-1cm-1
Variant MPN: 1089
Format: Blue solid
Solubility: Water, DMSO, DMF, MeOH
Spectral Information: Abs/Em = 647/663 nm
Comments: CF280: 0.05; CF260: 0.05
Storage: -20C. Desiccate
Shipped: Frozen - Dry Ice


1. Lueckgen A, Garske DS, Ellinghaus A, Mooney DJ, Duda GN, Cipitria A. Dual alginate crosslinking for local patterning of biophysical and biochemical properties [published online ahead of print, 2020 Jul 28]. Acta Biomater. 2020;S1742-7061(20)30433-5. View article 

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