DBCO-PEG5-Acid
An amine-reactive building block with enhanced stability and solubility in aqueous media.
Highlights:
- Biocompatible – click reaction occurs efficiently under mild buffer conditions; requires no accessory reagents such as a copper catalyst or reducing agents (e.g. DTT)
- Chemoselective – azide and DBCO groups do not react or interfere with other functional groups found in biological samples, but conjugate to one another with high efficiency
- Extended PEG4 Spacer – helps reduce aggregation, minimizes steric hindrance, and enhances solubility in aqueous buffers
DBCO-PEG5-Acid is a polyethylene glycol-containing reagent with terminal carboxylic acid (–COOH) that can be reacted with primary or secondary amine groups in the presence activators (e.g. EDC) forming a stable amide bond. The PEG spacer arm is hydrophilic and provides greater solubility to labeled molecules compared to reagents having only hydrocarbon spacers. The PEG spacer arm also gives the reagent a long and flexible connection to minimize steric hindrance involved with reacting with complementary azido-modified molecules.
An amine-reactive building block with enhanced stability and solubility in aqueous media.
Highlights:
- Biocompatible – click reaction occurs efficiently under mild buffer conditions; requires no accessory reagents such as a copper catalyst or reducing agents (e.g. DTT)
- Chemoselective – azide and DBCO groups do not react or interfere with other functional groups found in biological samples, but conjugate to one another with high efficiency
- Extended PEG4 Spacer – helps reduce aggregation, minimizes steric hindrance, and enhances solubility in aqueous buffers
DBCO-PEG5-Acid is a polyethylene glycol-containing reagent with terminal carboxylic acid (–COOH) that can be reacted with primary or secondary amine groups in the presence activators (e.g. EDC) forming a stable amide bond. The PEG spacer arm is hydrophilic and provides greater solubility to labeled molecules compared to reagents having only hydrocarbon spacers. The PEG spacer arm also gives the reagent a long and flexible connection to minimize steric hindrance involved with reacting with complementary azido-modified molecules.
| Catalog Number | Product | DataSheet | Size | AVAILABILITY | Price | Qty |
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Specifications
| Product Type: | Small Molecule |
| Name: | DBCO-PEG5-Acid |
| Chemical Formula: | C32H40N2O9 |
| Molecular Weight: | 596.67 |
| Variant MPN: | A101P |
| Format: | Yellow to slightly orange oil |
| Solubility: | DMSO, DMF, DCM, THF, CHCl3 |
| Storage: | -20C. Desiccate |
| Shipped: | Frozen overnight - Ambient |
Documentation
References
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