This mouse monoclonal antibody was generated against a recombinant form of the first immunoglobulin domain of obscurin-A/obscurin-B, and recognizes the N-terminus of human, mouse, and rat Obscurin Immunoglobulin domain 1 (amino acids 1-100).
Discovered about a decade ago, obscurin (720/870 kDa) is a member of a family of giant proteins originally identified in striated muscles that are essential for normal muscle formation and function. Recent evidence has indicated that variants of obscurin (‘‘obscurins’’) are expressed in non-muscle tissues too, where they contribute to distinct cellular processes. Dysfunction or abrogation of obscurins has been implicated in the development of several pathological conditions, including cardiac hypertrophy and cancer.
From the laboratories of Aikaterini Kontrogianni-Konstantopoulos, PhD and Robert J. Bloch, PhD, University of Maryland, Baltimore.
Part of The Investigator's Annexe program.
|Antigen:||Obscurin Immunoglobulin domain 1|
|Molecular Weight:||720-870 kDa|
|Reactivity:||Mouse, Rat, Human|
|Immunogen:||Recombinant protein containing the first immunoglobulin domain of obscurin-A/obscurin-B|
|Epitope:||Obscurin Immunoglobulin domain 1 (aa1-100)|
|Buffer:||Cell culture supernatant|
|Tested Applications:||Immunoblotting/ immunofluorescence,1:20-1:30;|
|Storage:||4C Short Term, -80C Long Term|
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