Trans-Cyclooctene (TCO)-PEG4-NHS ester is an amine-reactive labeling reagent with enhanced water solubility provided by a PEG4 spacer.
TCO-PEG4-NHS ester reacts specifically and efficiently with a primary amine (e.g., side chain of lysine residues or aminosilane-coated surfaces) at pH 7-9 to form a covalent bond. The hydrophilic polyethylene glycol (PEG) spacer arm imparts water solubility that is transferred to the labeled molecule, thus reducing aggregation of labeled proteins stored in solution. The PEG spacer arm provides a long and flexible connection that minimizes steric hindrance involved with ligation to complementary tetrazine-containing molecules.
|Product Type:||Small Molecule|
|Name:||Trans-Cyclooctene (TCO)-PEG4-NHS Ester|
|Purity:||>90%, H NMR|
|Solubility:||DCM, Chloroform, DMSO, DMF|
|Storage:||Upon receipt store at -20C|
Applications: Protein-protein conjugation, protein-antibody conjugation, protein-small molecule conjugation, 18F radiolabeling, protein-oligonucleotide conjugation, surface modification
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