Cy5 - Methyltetrazine

Cy5-Tetrazine is a fluorescent probe useful for chemoselective labeling and detection of TCO-tagged molecules.

Highlights:

  • Biocompatible – click reaction occurs efficiently under mild buffer conditions; requires no accessory reagents such as a copper catalyst or reducing agents (e.g. DTT)
  • Chemoselective – tetzines and trans-cyclooctene groups do not react or interfere with other functional groups found in biological samples but conjugate to one another with high efficiency
  • Unprecedented kinetics – inverse-electron demand Diels-Alder chemistry is the fastest bioorthogonal ligation available, delivering conjugates within 30 min at 1 mg/mL concentrations

Tetrazine-activated fluorescent dyes are well suited for the detection of TCO-labeled biopolymers. The inverse-electron demand Diels-Alder cycloaddition reaction of TCO with tetrazines is a bioorthogonal reaction that possesses exceptional kinetics (k > 800 M-1s-1) and selectivity. Such excellent reaction rate constants are unparalleled by any other bioorthogonal reaction pair described to date.

Catalog Number Product Size AVAILABILITY Price Qty
FCC223
Cy5 - Methyltetrazine, 1 mg
1mg In stock
Regular Price:$120.00
FCC224
Cy5 - Methyltetrazine, 5 mg
5mg In stock
Regular Price:$329.00
Specifications

Product Type: Small Molecule
Name: Cy5-Tetrazine
Chemical Formula: C44H51N7O10S3(protonated)
Molecular Weight: 934.10 (protonated)
Variant MPN: 1019-1
Purity: >95%, HPLC
Solubility: DMSO, DMF, Water
Storage: Upon receipt store at -20C
Shipped: Ambient temperature

Documentation

  Cy5-Tetrazine Data Sheet

If you publish research with this product, please let us know so we can cite your paper.

References
  1. Koshy ST, Desai RM, Joly P, Li J, Bagrodia RK, Lewin SA, Joshi NS, Mooney DJ. Click-Crosslinked Injectable Gelatin Hydrogels. Adv Healthc Mater. 2016 Mar 9;5(5):541-7. doi: 10.1002/adhm.201500757. PubMed PMID: 26806652; PubMed Central View Article

If you publish research with this product, please let us know so we can cite your paper.

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