Propargyl-Maleimide
Propargyl-Maleimide is a short-length, maleimide-activated, sulfhydryl-reactive labeling reagent possessing a short hydrocarbon spacer.
Highlights:
- Chemoselective – azide and alkyne groups do not react or interfere with other functional groups found in biological samples but conjugate to one another with high efficiency
- Solubility – reagent easily dissolves in water-miscible solvents for subsequent dilution into aqueous reaction mixtures
- Sulfhydryl-reactive – maleimides react rapidly with reduced cysteines or other molecules that contain reduced thiols (–SH groups) forming a stable thioether bond
- Very Short Spacer – 4 atom spacer arm keeps alkyne group close to tagged molecules
Propargyl-Maleimide enables simple and efficient incorporation of terminal alkyne group onto antibodies, cysteine-containing peptides or other thiol-containing molecules. The alkyne group reacts with azides by a mechanism known as Cu-catalyzed click reaction enabling efficient and specific conjugation of derivatized molecules in biological samples.
Propargyl-Maleimide is a short-length, maleimide-activated, sulfhydryl-reactive labeling reagent possessing a short hydrocarbon spacer.
Highlights:
- Chemoselective – azide and alkyne groups do not react or interfere with other functional groups found in biological samples but conjugate to one another with high efficiency
- Solubility – reagent easily dissolves in water-miscible solvents for subsequent dilution into aqueous reaction mixtures
- Sulfhydryl-reactive – maleimides react rapidly with reduced cysteines or other molecules that contain reduced thiols (–SH groups) forming a stable thioether bond
- Very Short Spacer – 4 atom spacer arm keeps alkyne group close to tagged molecules
Propargyl-Maleimide enables simple and efficient incorporation of terminal alkyne group onto antibodies, cysteine-containing peptides or other thiol-containing molecules. The alkyne group reacts with azides by a mechanism known as Cu-catalyzed click reaction enabling efficient and specific conjugation of derivatized molecules in biological samples.
| Catalog Number | Product | DataSheet | Size | AVAILABILITY | Price | Qty |
|---|
Specifications
| Product Type: | Small Molecule |
| Name: | Propargyl-Maleimide (1-(Prop-2-yn-1-yl)-1H-pyrrole-2,5-dione ) |
| Chemical Formula: | C7H5NO2 |
| Molecular Weight: | 130.12 |
| Variant MPN: | TA113 |
| Format: | Slightly yellow solid |
| Storage: | -20C. Desiccate |
| Shipped: | Ambient |
References
- Tebo AG, Quaranta A, Herrero C, Pecoraro VL, Aukauloo A. Intramolecular Photogeneration of a Tyrosine Radical in a Designed Protein. ChemPhotoChem. 2017 Mar;1(3):89-92. View Article
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