Methyllycaconitine citrate (MLA)

Methyllycaconitine Citrate is the citrate salt of Methyllycaconitine (MLA), which is a norditerpenoid alkaloid isolated from Delphinium ajacis and acts as a nicotinic receptor antagonist.

Methyllycaconitine is a selective and potent antagonist of the a7 neuronal nicotinic acetylcholine receptors (nAChR) (Ki = 1.4 nM). nAChR are ligand-gated ion channels that mediate fast synaptic transmission. MLA acts as a nicotinic receptor antagonist that reduces synaptic efficacy and blocks neuromuscular transmission. The toxicity of the alkaloid is thought to be due to the substituent at C14 and the ester function in C18, which determines the potency and possibly the mechanism of nicotinic acetylcholine receptor blockade for MLA.

Catalog Number Product DataSheet Size AVAILABILITY Price Qty
FAP045
Methyllycaconitine citrate (MLA), 10mg
10mg 1-2 weeks
Regular Price:$151.50
On Sale:
FAP046
Methyllycaconitine citrate (MLA), 50mg
50mg 1-2 weeks
Regular Price:$606.00
On Sale:
Specifications

Product Type: Small Molecule
Chemical Formula: C37H50N2O10, C6H8O7
CAS number: 21019-30-7
Molecular Weight: 874.9
Format: White crystalline solid
Purity: >99 % determined by HPLC
Solubility: Soluble in water and DMSO
Stability: Stable over extended period at -20C
Storage: -20C, avoid exposure to oxygen and direct sunlight
Shipped: Cold Pack

Data

Methyllycaconitine HPLC Chromatogram.


Purification Notes: Isolated from Delphinium ajacis using long-column chromatography and then stabilized by crystalization as a citrate salt.

References
  1. Dobelis P, Madl J, Pfister J, Manners G and Walrond J. (1999). Effects of Delphinium alkaloids on neuromuscular transmission. JPET 291: 538-546.
  2. Ward J, Cockcroft V, Lunt G, Smillie F and Wonnacott S. (1990). Methyllycaconitine: a selective probe for neuronal alpha-bungarotoxin binding sites. FEBS letters 270: 45-48.

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