Methyllycaconitine Citrate is the citrate salt of Methyllycaconitine (MLA), which is a norditerpenoid alkaloid isolated from Delphinium ajacis and acts as a nicotinic receptor antagonist.
Methyllycaconitine is a selective and potent antagonist of the a7 neuronal nicotinic acetylcholine receptors (nAChR) (Ki = 1.4 nM). nAChR are ligand-gated ion channels that mediate fast synaptic transmission. MLA acts as a nicotinic receptor antagonist that reduces synaptic efficacy and blocks neuromuscular transmission. The toxicity of the alkaloid is thought to be due to the substituent at C14 and the ester function in C18, which determines the potency and possibly the mechanism of nicotinic acetylcholine receptor blockade for MLA.
|Product Type:||Small Molecule|
|Chemical Formula:||C37H50N2O10, C6H8O7|
|Format:||White crystalline solid|
|Purity:||>99 % determined by HPLC|
|Solubility:||Soluble in water and DMSO|
|Stability:||Stable over extended period at -20C|
|Storage:||-20C, avoid exposure to oxygen and direct sunlight|
Methyllycaconitine HPLC Chromatogram.
Purification Notes: Isolated from Delphinium ajacis using long-column chromatography and then stabilized by crystalization as a citrate salt.
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