This mouse IgG monoclonal antibody recognizes an epitope within amino acids 414-433 of the cytoplasmic tail region of human cluster of differentiation antignen 4 (CD4).
Recombinant versions available from our sister company, Absolute Antibody:
Eukaryotic genes end with one of three stop codons, UGA, UAA, or UAG. Of these three, UGA is unique. In addition to functioning as a stop codon, UGA is also the codon for the twenty-first amino acid, selenocysteine. The biological bases for the dual function of the UGA codon are not entirely clear. Selenocysteine plays a critical role in physiology, and perturbations of selenium intake and metabolism can have disastrous consequences. CD4 is a membrane glycoprotein of T lymphocytes that interacts with major histocompatibility complex class II antigenes and is also a receptor for the human immunodeficiency virus (HIV). The cytoplasmic tail region transmits a signal in response to p56-lck. HIV nef is also known to interact with the cytoplasmic tail of CD4.
From the laboratory of Ethan W. Taylor, PhD, University of Georgia.
|Name:||CD4, Cytoplasmic Tail [10C12] Antibody|
|Antigen:||LSEKKTCQCPHRFQKTCSPI of human CD4. epitope within amino acids 414 and 433 of the cytoplasmic tail region of human CD4.|
Recombinant versions: see product name
|Clone Name:||10C12, also known as Antibody 024|
|Reactivity:||Human (possibly others)|
|Immunogen:||Multiple antigenic peptide, a tetramer linked through a lysine backbone|
|Purification Method:||Protein G Affinity|
EGA902: PBS, 0.05% (w/v) Sodium Azide
Recombinant versions: PBS with 0.02% Proclin 300
|Tested Applications:||For ELISA: 10-25 ug/ml (Jurkat, H9, HeLa). For IF: 5-12 ug/ml. For Immunoblotting: 5-11ug/ml|
|Storage:||-20C (long term)|
If you publish research with this product, please let us know so we can cite your paper.