This IgG monoclonal antibody was generated against methylglyoxal (MG)-modified ovalbumin, and is reactive against human, mouse and rat MG.
Recombinant versions available from our sister company, Absolute Antibody:
Methylglyoxal (MG) also referred to as pyruvaldehyde or 2-oxopropanal is formed as a side product of several metabolic pathways. Importantly, it has shown to be involved in the formation of advanced glycation end products otherwise known as AGEs. AGEs are formed both outside and inside the body. AGEs are substances that can be a factor in the development or worsening of many degenerative diseases including Diabetes and Alzheimer's disease.
From the laboratory of Helen Vlassara, MD, Icahn School of Medicine at Mount Sinai.
|Name:||AGE, Methylglyoxal [3D11] Antibody|
|Molecular Weight:||45.4 kDa|
Recombinant versions: see product name
|Reactivity:||Human, Mouse, Rat|
|Purification Method:||Protein G Affinity Chromatography|
EMS301: 0.1M Sodium Phosphate, pH 7.4, 0.15M NaCl, 0.05% (w/v) Sodium Azide
Recombinant versions: PBS with 0.02% Proclin 300
|Tested Applications:||WB (1:800-2000), IHC (1:10-20), ELISA (1:1000)|
Binding inhibition curve of anti-MG derivative (MG3D11)
Affinity of mouse monoclonal antibody (MG3D11) was determined by a competitive ELISA. Competitive inhibition of antibody binding by modified and unmodified proteins (left) or lipid lipoprotein preparations (right)
Adapted from: Cai W., et. al Mol Med 8: 337-346, 2002.
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