Anti-RAGE, V Domain [2A11] Antibody

This mouse IgG1 monoclonal antibody [2A11] is specific for the V-domain of human advanced glycosylation end product-specific receptor (AGER, RAGE).


  • Inhibits activation of RAGE by blocking the V-domain
  • Recognizes both glycosolated and unglycosolated forms
  • Suitable for Western Blot , Immunohistochemistry, Immunofluorescence, ELISA and Flow Cytometry applications

Recombinant versions available from our sister company, Absolute Antibody:

Advanced glycosylation end product-specific receptor (AGER, RAGE) mediates interactions of advanced glycosylation end products (AGE), nonenzymatically glycosylated proteins. AGE/RAGE signaling plays an important role in regulating the production/expression of TNF-alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. Interaction with S100A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key proinflammatory mediators. Interaction with S100B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling. RAGE acts as a receptor for amyloid beta peptide and contributes to the translocation of amyloid-beta peptide (ABPP) across the cell membrane in cortical neurons. The V domain binds multiple ligands that elicit sustained inflammation associated with diabetes, cancer, Alzheimer’s, multiple sclerosis, and other diseases.

From the laboratory of Estelle Leclerc, PhD, North Dakota State University.

Catalog Number Product DataSheet Size AVAILABILITY Price Qty
Anti-RAGE, V Domain [2A11] Antibody
100ug In stock
Regular Price:$350.00
On Sale:
Recombinant Anti-RAGE [2A11], Mouse, IgG1
200ug In stock
Regular Price:$470.00
On Sale:
Recombinant Anti-RAGE [2A11], Rabbit, IgG
200ug In stock
Regular Price:$470.00
On Sale:

Product Type: Antibody
Name: RAGE, V Domain [2A11] Antibody
Antigen: Advanced glycosylation end product-specific receptor (AGER, RAGE)
Accession ID: Q15109
Molecular Weight: 42.8 kDa
Isotype: ENS001: IgG1
Recombinant versions: see product name
Clonality: Monoclonal
Clone Name: 2A11
Reactivity: Human (others not tested)
Species Immunized: Mouse
Purification Method: Protein G
Buffer: ENS001: 0.1M Sodium Phosphate, pH 7.4, 0.15M NaCl, 0.05% (w/v) Sodium Azide
Recombinant versions: PBS with 0.02% Proclin 300
Tested Applications: WB, IHC (1-5ug/mL), IF (1ug/mL), Flow Cytometry (1ug/mL), ELISA (1ug/mL); Has not been tested on parafin-embedded sections
Storage: -20C
Shipped: Cold packs

From the laboratory of Estelle Leclerc, PhD, North Dakota State University.

If you publish research with this product, please let us know so we can cite your paper.