This IgG2b mouse antibody was generated against amino acids 37-53 of rat GABA-A receptor gamma2 subunit GABRG2 and is specific for the N-terminal extracellular domain, allowing for the detection of surface expressed receptors for live imaging.
Recombinant versions available from our sister company, Absolute Antibody:
GABA-A receptors are ligand-gated neurotransmitter receptors that function to mediate the fast synaptic inhibition within the brain. They are pentamers, composed from a variety of classes of subunits with gamma being just one class. Each subunit is composed of an extracellular N-terminal domain, four membrane spanning units, and a small extracellular C-terminal segment. Several mutations in the GABA(A) receptor subunit gamma-2 expression have been linked to epileptic syndromes that result in fibrile seizures.
From the laboratory of Jaideep Kapur, MD, PhD, University of Virginia.
|Name:||Anti-GABA-A Receptor, Gamma 2 Subunit [10F10-C1-B8]|
|Antigen:||GABA-A Receptor Gamma 2 Subunit|
|Accession ID:||P18508, NP_899156|
Recombinant versions: see product name
|Reactivity:||Reactive against the N-terminal extracellular domain (amino acids 37-53) of the gamma2 subunit of the GABA-A protein in rats|
|Immunogen:||Generated against the gamma2 subunit of the GABA-A protein from rats|
|Epitope:||N-terminal extracellular domain (amino acids 37-53)|
|Purification Method:||Protein G|
EG1401: PBS, 0.05% (w/v) Sodium Azide
Recombinant versions: PBS with 0.02% Proclin 300
|Tested Applications:||WB, IF, IHC, IP|
For western blot, 1:2,000 dilution recommended.
For IHC, 1:250 dilution recommeneded.
If you publish research with this product, please let us know so we can cite your paper.