This mouse IgG2a monoclonal antibody was generated against flavivirus envelope proteins and recognizes the domain II of protein E (fusion loop) of flavivirus.
Recombinant versions available from our sister company, Absolute Antibody:
The flavivirus inlcudes West Nile virus, dengue virus, tick-borne encephalitis virus, yellow fever virus, Zika virus and several other viruses which may cause encephalitis. Flaviviruses have a (+) sense RNA genome and replicate in the cytoplasm of the host cells. The genome mimics the cellular mRNA molecule in all aspects except for the absence of the poly-adenylated (poly-A) tail. This feature allows the virus to exploit cellular apparatus to synthesise both structural and non-structural proteins, during replication.
|Name:||Anti-Flavivirus E Protein [D1-4G2-4-15] Antibody|
|Antigen:||Flavivirus Envelope (E) Protein|
FCG001: IgG2a kappa
Recombinant versions: see product name
|Immunogen:||Flavivirus envelope proteins|
|Purification Method:||Protein G|
FCG001:PBS, pH 7.2
Recombinant versions: PBS with 0.02% Proclin 300
|Storage:||Store at 4C for up to 3 months. For longer storage, aliquot and store at -20C.|
Detection of ZIKV via immunofluorescence
Sample confocal images of forebrain-specific hNPCs 56 hr after infection with ZIKV supernatant, immunostained for ZIKV envelop protein (ZIKVE; green) and DAPI (gray). Cells were differentiated from the C1-2 hiPSC line. Scale bars, 20 ?m.
Adapted from: Tang H, et al. Cell Stem Cell. 2016 May 5;18(5):587-90.
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