Influenza COBRA P1 and CA/09 Antibodies

These IgG mouse monoclonal antibodies were raised against Influenza A H1N1, with specificity to Hemagglutinin COBRA P1 or CA/09 viruses.

Highlights:

  • Specifity to COBRA P1 or CA/09, respectively
  • Suitable for Elisa, Western Blot, HAI assay, Biolayer interferometry applications

Influenza virus contains two major surface glycoproteins, haemagglutinin (HA) and neuraminidase (NA), that dictate how the subtypes are categorized (depending on the type of H or N antigens they express with metabolic synergy). There are 11 and 18 different hemagglutinin and neuraminidase subtypes, respectively. Amino acid substitutions (mutations) in these two proteins result in variations among the circulating seasonal strains and allow for the virus to evade host immunity. This may pose a challenge for long-lasting immunity and vaccines efficacy.

Computationally Optimized Broadly Reactive Antigens is a strategy, termed COBRA, where synthetic HA antigens are generated to elicit protective antibodies against a broad spectrum of influenza viruses compared with antibodies elicited by a wild-type, strain-based vaccine. Influenza A H1N1 is a subclass of the Influenza A virus, and it is the only one (out of the influenza virus group) with the ability to cause flu pandemics, in addition to the seasonal epidemics. A/California/07/2009 is a Influenza A H1N1 virus strain.

From the laboratories of Giuseppe A. Sautto, PhD and Ted M. Ross, PhD, University of Georgia.

Catalog Number Product DataSheet Size AVAILABILITY Price Qty
EGA318
Anti-Influenza A H1N1, Hemagglutinin COBRA P1 [1F8] Antibody
100ug Currently unavailable
Regular Price:$299.00
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EGA319
Anti-Influenza A H1N1, Hemagglutinin COBRA P1 [4E7] Antibody
100ug Currently unavailable
Regular Price:$299.00
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EGA320
Anti-Influenza A H1N1, Hemagglutinin COBRA P1 [3H6] Antibody
100ug Currently unavailable
Regular Price:$299.00
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EGA321
Anti-Influenza A H1N1, Hemagglutinin COBRA P1 [2C5] Antibody
100ug Currently unavailable
Regular Price:$299.00
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EGA322
Anti-Influenza A H1N1, Hemagglutinin COBRA P1 [4H11] Antibody
100ug Currently unavailable
Regular Price:$299.00
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EGA323
Anti-Influenza A H1N1, Hemagglutinin CA/09 [1E6] Antibody
100ug Currently unavailable
Regular Price:$299.00
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EGA324
Anti-Influenza A H1N1, Hemagglutinin CA/09 [3B6] Antibody
100ug Currently unavailable
Regular Price:$299.00
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EGA325
Anti-Influenza A H1N1, Hemagglutinin COBRA P1 [4E6] Antibody
100ug Currently unavailable
Regular Price:$299.00
On Sale:
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EGA326
Anti-Influenza A H1N1, Hemagglutinin COBRA P1 [3A1] Antibody
100ug Currently unavailable
Regular Price:$299.00
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EGA327
Anti-Influenza A H1N1, Hemagglutinin COBRA P1 [1A12] Antibody
100ug Currently unavailable
Regular Price:$299.00
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EGA328
Anti-Influenza A H1N1, Hemagglutinin COBRA P1 [1E2] Antibody
100ug Currently unavailable
Regular Price:$299.00
On Sale:
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EGA329
Anti-Influenza A H1N1, Hemagglutinin COBRA P1 [2H6] Antibody
100ug Currently unavailable
Regular Price:$299.00
On Sale:
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EGA330
Anti-Influenza A H1N1, Hemagglutinin COBRA P1 [4A3] Antibody
100ug Currently unavailable
Regular Price:$299.00
On Sale:
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EGA331
Anti-Influenza A H1N1, Hemagglutinin COBRA P1 [4G7] Antibody
100ug Currently unavailable
Regular Price:$299.00
On Sale:
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EGA332
Anti-Influenza A H1N1, Hemagglutinin COBRA P1 [2B9] Antibody
100ug Currently unavailable
Regular Price:$299.00
On Sale:
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EGA333
Anti-Influenza A H1N1, Hemagglutinin COBRA P1 [4B3] Antibody
100ug Currently unavailable
Regular Price:$299.00
On Sale:
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EGA334
Anti-Influenza A H1N1, Hemagglutinin COBRA P1 [3D1] Antibody
100ug Currently unavailable
Regular Price:$299.00
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EGA335
Anti-Influenza A H1N1, Hemagglutinin COBRA P1 [2A10] Antibody
100ug 4-6 weeks
Regular Price:$299.00
On Sale:
EGA336
Anti-Influenza A H1N1, Hemagglutinin COBRA P1 [3D3] Antibody
100ug Currently unavailable
Regular Price:$299.00
On Sale:
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EGA337
Anti-Influenza A H1N1, Hemagglutinin COBRA P1 [2D8] Antibody
100ug Currently unavailable
Regular Price:$299.00
On Sale:
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EGA338
Anti-Influenza A H1N1, Hemagglutinin COBRA P1 [4H3] Antibody
100ug Currently unavailable
Regular Price:$299.00
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EGA339
Anti-Influenza A H1N1, Hemagglutinin COBRA P1 [2A5] Antibody
100ug Currently unavailable
Regular Price:$299.00
On Sale:
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EGA340
Anti-Influenza A H1N1, Hemagglutinin COBRA P1 [4G10] Antibody
100ug Currently unavailable
Regular Price:$299.00
On Sale:
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EGA341
Anti-Influenza A H1N1, Hemagglutinin COBRA P1 [4C5] Antibody
100ug Currently unavailable
Regular Price:$299.00
On Sale:
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EGA342
Anti-Influenza A H1N1, Hemagglutinin COBRA P1 [4A8] Antibody
100ug Currently unavailable
Regular Price:$299.00
On Sale:
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EGA343
Anti-Influenza A H1N1, Hemagglutinin COBRA P1 [4B5] Antibody
100ug Currently unavailable
Regular Price:$299.00
On Sale:
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EGA344
Anti-Influenza A H1N1, Hemagglutinin COBRA P1 [3E2] Antibody
100ug 4-6 weeks
Regular Price:$299.00
On Sale:
EGA345
Anti-Influenza A H1N1, Hemagglutinin COBRA P1 [3D7] Antibody
100ug Currently unavailable
Regular Price:$299.00
On Sale:
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EGA346
Anti-Influenza A H1N1, Hemagglutinin COBRA P1 [1B7] Antibody
100ug Currently unavailable
Regular Price:$299.00
On Sale:
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EGA347
Anti-Influenza A H1N1, Hemagglutinin COBRA P1 [3D10] Antibody
100ug Currently unavailable
Regular Price:$299.00
On Sale:
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EGA348
Anti-Influenza A H1N1, Hemagglutinin CA/09 [2A12] Antibody
100ug Currently unavailable
Regular Price:$299.00
On Sale:
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EGA349
Anti-Influenza A H1N1, Hemagglutinin CA/09 [2B11] Antibody
100ug Currently unavailable
Regular Price:$299.00
On Sale:
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EGA350
Anti-Influenza A H1N1, Hemagglutinin CA/09 [1G12] Antibody
100ug Currently unavailable
Regular Price:$299.00
On Sale:
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EGA351
Anti-Influenza A H1N1, Hemagglutinin CA/09 [3G6] Antibody
100ug Currently unavailable
Regular Price:$299.00
On Sale:
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EGA352
Anti-Influenza A H1N1, Hemagglutinin CA/09 [5B-2A12] Antibody
100ug Currently unavailable
Regular Price:$299.00
On Sale:
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EGA353
Anti-Influenza A H1N1, Hemagglutinin CA/09 [2G7] Antibody
100ug Currently unavailable
Regular Price:$299.00
On Sale:
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EGA354
Anti-Influenza A H1N1, Hemagglutinin CA/09 [2F3] Antibody
100ug Currently unavailable
Regular Price:$299.00
On Sale:
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EGA355
Anti-Influenza A H1N1, Hemagglutinin CA/09 [3B8] Antibody
100ug Currently unavailable
Regular Price:$299.00
On Sale:
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EGA356
Anti-Influenza A H1N1, Hemagglutinin CA/09 [M2-2B9] Antibody
100ug Currently unavailable
Regular Price:$299.00
On Sale:
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Specifications

Product Type: Antibody
Name: Anti-Influenza A H1N1, Hemagglutinin COBRA P1 [1F8] Antibody
Alternative Name(s): Cobra P1, anti-H1N1 influenza HA, CA/09, anti-H1 Influenza HA CA/09
Antigen: Anti-H1N1 influenza hemagglutinin COBRA P1
Isotype: IgG2a,k
Clonality: Monoclonal
Clone Name: 1F8
Reactivity: virus
Specificity: COBRA P1
Immunogen: COBRA P1 influenza virus
Species Immunized: Mus musculus (BALB/c)
Epitope: conformational
Purification Method: Protein G
Buffer: PBS, 0.05% (w/v) Sodium Azide
Tested Applications: Elisa, Western Blot, HAI assay, Biolayer interferometry
Concentration: 1mg/mL
Comments: Broadly HAI+, broadly neutralizer
Storage: -20C
Shipped: Cold Packs

Data
Cat. Antibody Isotype Epitope Notes
EGA318 1F8 IgG2a,k conformational  Broadly HAI+, broadly neutralizer
EGA319 4E7 IgG2a,k conformational  HAI+ antibodies, neutralizers
EGA320 3H6 IgG1,k conformational  HAI+ antibodies, neutralizers
EGA321 2C5 IgG2a,k linear Stem-directed antibodies. Broadly reactive against group 1 subtype HA
EGA322 4H11 IgG1,k conformational 
EGA323 1E6 IgG2a,k conformational 
EGA324 3B6 IgG2a,k linear  Stem-directed antibodies. Broadly reactive against group 1 subtype HA
EGA325 4E6 IgG1,k linear
EGA326 3A1 IgG2b,k linear
EGA327 1A12 IgG1,k linear
EGA328 1E2 IgG1,k linear  reactive against influenza B HA 
EGA329 2H6 IgG1,k linear Stem-directed antibodies. Broadly reactive against group 1 subtype HA
EGA330 4A3 IgG1,k conformational  Stem-directed antibodies. Broadly reactive against group 1 subtype HA
EGA331 4G7 IgG1,k conformational  Stem-directed antibodies. Broadly reactive against group 1 subtype HA
EGA332 2B9 IgG1,k conformational  Stem-directed antibodies. Broadly reactive against group 1 subtype HA
EGA333 4B3 IgG1,k linear
EGA334 3D1 IgG1,k conformational 
EGA335 2A10 IgG1,k conformational 
EGA336 3D3 IgG2a,k conformational 
EGA337 2D8 IgG1,k conformational 
EGA338 4H3 IgG1,k conformational 
EGA339 2A5 IgG2a,k conformational 
EGA340 4G10 IgG1,k conformational  HAI+ antibodies, neutralizers
EGA341 4C5 IgG2b,k  conformational 
EGA342 4A8 IgG2a,k conformational  HAI+ antibodies, neutralizers
EGA343 4B5 IgG2a,k conformational  HAI+ antibodies, neutralizers
EGA344 3E2 IgG2a,k conformational  HAI+ antibodies, neutralizers
EGA345 3D7 IgG1,k conformational  HAI+ antibodies, neutralizers
EGA346 1B7 IgG1,k conformational 
EGA347 3D10 IgG1,k conformational 
EGA348 2A12 IgG2a,k conformational 
EGA349 2B11 IgG1,k conformational 
EGA350 1G12 IgG1,k conformational  HAI+ antibodies, neutralizers
EGA351 3G6 IgG1,k conformational 
EGA352 5B-2A12 IgG1,k conformational  HAI+ antibodies, neutralizers
EGA353 2G7 IgG1,k conformational  HAI+ antibodies, neutralizers
EGA354 2F3 IgG1,k conformational  HAI+ antibodies, neutralizers
EGA355 3B8 IgG1,k conformational  HAI+ antibodies, neutralizers
EGA356 M2-2B9 IgG2a,k conformational  HAI+ antibodies, neutralizers
Provider
From the laboratories of Giuseppe A. Sautto, PhD and Ted M. Ross, PhD, University of Georgia.
References
  1. Sautto GA, Kirchenbaum GA, Abreu RB, Ecker JW, Pierce SR, Kleanthous H, Ross TM. A Computationally Optimized Broadly Reactive Antigen Subtype-Specific Influenza Vaccine Strategy Elicits Unique Potent Broadly Neutralizing Antibodies against Hemagglutinin. J Immunol. 2020 Jan 15;204(2):375-385. doi: 10.4049/jimmunol.1900379. Epub 2019 Dec 6. PMID: 31811019.

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