Anti-Fibroblast Activation Protein (FAP) [73.3] Antibody
![Anti-Fibroblast activation protein (FAP) [73.3] Antibody](https://www.kerafast.com/MediaStorage/Product/Images/Large/1756_2001202001270017550.jpg "Anti-Fibroblast Activation Protein (FAP) [73.3] Antibody")
This mouse IgG1 monoclonal antibody was raised against Fibroblast Activation Protein (FAP) -expressing 3T3 cells and recognizes mouse FAP.
Highlights:
- Reacts with mouse FAP
- Suitable for Western Blot, ELISA and Immunoprecipitation applications
Fibroblast activation protein (FAP), also known as seprase, is a cell surface, type II integral transmembrane serine protease encoded by the Fap gene. It displays in vitro gelatinase, endopeptidase, and potentially collagenase activity. FAP has been detected on pericytes, bone marrow-derived mesenchymal stem cells, and a small population of macrophages. FAP is highly expressed on mesenchymal cells during embryogenesis and is repressed shortly after birth. FAP expression is up-regulated on activated fibroblasts in conditions associated with matrix remodeling, such as sites of inflammation in disease including wound healing, fibrosis, rheumatoid arthritis and osteoarthritis, liver disease, inflammatory bowel diseases, and several types of cancer.
From the laboratory of Ellen Puré, PhD, The Wistar Institute.
This mouse IgG1 monoclonal antibody was raised against Fibroblast Activation Protein (FAP) -expressing 3T3 cells and recognizes mouse FAP.
Highlights:
- Reacts with mouse FAP
- Suitable for Western Blot, ELISA and Immunoprecipitation applications
Fibroblast activation protein (FAP), also known as seprase, is a cell surface, type II integral transmembrane serine protease encoded by the Fap gene. It displays in vitro gelatinase, endopeptidase, and potentially collagenase activity. FAP has been detected on pericytes, bone marrow-derived mesenchymal stem cells, and a small population of macrophages. FAP is highly expressed on mesenchymal cells during embryogenesis and is repressed shortly after birth. FAP expression is up-regulated on activated fibroblasts in conditions associated with matrix remodeling, such as sites of inflammation in disease including wound healing, fibrosis, rheumatoid arthritis and osteoarthritis, liver disease, inflammatory bowel diseases, and several types of cancer.
From the laboratory of Ellen Puré, PhD, The Wistar Institute.
| Product Type: | Antibody |
| Antigen: | FAP |
| Accession ID: | Q12884 |
| Molecular Weight: | ~95 kDa |
| Isotype: | IgG1 |
| Clonality: | Monoclonal |
| Clone Name: | 73.3 |
| Reactivity: | Mouse |
| Immunogen: | FAP-expressing 3T3 cells |
| Species Immunized: | Mouse |
| Purification Method: | Protein G |
| Buffer: | 0.1M Sodium Phosphate, pH 7.4, 0.15M NaCl, 0.05% (w/v) Sodium Azide |
| Tested Applications: | WB, ELISA, IP |
| Storage: | -20C |
| Shipped: | Cold Packs |
- Wang LC, Lo A, Scholler J, Sun J, Majumdar RS, Kapoor V, Antzis M, Cotner CE, Johnson LA, Durham AC, Solomides CC, June CH, Puré E, Albelda SM. Targeting fibroblast activation protein in tumor stroma with chimeric antigen receptor T cells can inhibit tumor growth and augment host immunity without severe toxicity. Cancer Immunol Res. 2014 Feb;2(2):154-66.
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