Functionalized Gold Nanoparticles

These biocompatible liposome-encapsulated gold nanoparticles comprising of cell penetrating peptides and fluorescent dyes Oregon Green (OG) or Lissamine Rhodamine B (LSRSH) are readily taken up into cells and can be used for use for live cell imaging.


  • Homogenous non-aggregated dispersions of uniform 20 nm spheres (520 nm visible surface plasmon resonance (SPR))
  • Surface functionalized with a robust anchored and tightly packed hybrid lipid-membrane that is stable to membrane rearrangement and instability
  • Surface chemistry comprised of biocompatible ligands that minimize nanoparticle-nanoparticle interactions, enhance cellular recognition, and increase nanoparticle uptake
  • Customized hybrid membrane composition available with cell-penetrating RGD peptide as well as Oregon Green 488 (OG) and Lissamine Rhodamine B (LSRSH) dyes (excitation/emission maxima ~560/580 nm) for in vitro and in vivo studies
  • Can be used for a variety of imaging applications such as optical coherence tomography, x-ray CT imaging, and fluorescence spectroscopy
  • Purification methods remove free unbound and excess lipids, dyes, or salts
  • Suitable for IGDD applications, biomedical applications for use in therapuetics, prosthetics, drug delivery and cellular labeling and imaging; Possible uses also in nanoparticle ink printing and antimicrobial agents

Functionalized Gold Nanoparticles contain a hybrid bilayer membrane coated (HBM) used as robust, stable and targeted IGDD platforms that can be used as drug delivery and imaging agents.

From the laboratory of Marilyn R. Mackiewicz, PhD, Portland State University.

Catalog Number Product Size AVAILABILITY Price Qty
10mL at 1 OD In stock
Price: $475.00
10mL at 1 OD In stock
Price: $475.00
Product Type: Small Molecule
Functionalization: Lipids, RGD cell penetrating peptide, Oregon Green™ 488 (OG) or lissamine rhodamine B sulfonyl (LSRSH), hexanethiol
Particle Morphology: Spherical
Format: Liquid
Concentration: 1.0 O.D. or 6.0 x 10 entities/mL
Size Distribution: ± 3nM
Mean Diameter: 20 nm
Comments: pH can be adjusted with 1M HEPES (pH 6) or 1M PBS (pH 8) by adding 10 µL of 1 M buffer to every 1000 µL of nanoparticles
Storage: 4C
Shipped: Cold Packs

Functionalized Gold Nanoparticles

Scheme 1: Schematic diagram of Hybrid bilayer membrane-coated (HBM) nanoparticles.

Cyanide (CN-) Test

Scheme 2: Addition of cyanide (CN-­‐) to hybrid lipid-­‐coated AuNP (Scheme 2, A, (a)) showed no change in the optical density (O.D.) or localized surface plasmon resonance (LSPR) characteristic of AuNPs (Scheme 2, A, (b)) in the UV-­‐Vis spectra.

From the laboratory of Marilyn R. Mackiewicz, PhD, Portland State University.
  1. Mackiewicz MR, Hodges HL, Reed SM. C - Reactive Protein Induced Rearrangement of Phosphatidylcholine on Nanoparticle Mimics of Lipoprotein Particles. The journal of physical chemistry B. 2010;114(16):5556-5562. doi:10.1021/jp911617q.
  2. Mackiewicz MR,Sitaula S, Reed SM. Gold nanoparticles become stable to cyanide etch when coated with hybrid lipid bilayers. Chem. Commun., 2008,0, 3013-3015. 15 May 2008.

If you publish research with this product, please let us know so we can cite your paper.