Anti-SNX9, Cytoplasmic Domain Antibody

This rabbit IgG polyclonal antibody was generated against amino acids 6-595 of SNX9 (SH3PX1) and is specific for mouse SNX9.

Sorting nexin (SNX) proteins are members of a large family of hydrophilic PX (phospholipid-binding motif) domain-containing proteins that interact with a variety of receptor types. The ability of SNXs to bind specific phospholipids, as well as their tendency to form protein-protein complexes, suggests a role for these proteins in cellular membrane trafficking and protein sorting.

Sorting nexin-9 (SNX9, or SH3PX1) binds to the cytoplasmic domain of ADAMs9 and 15 and to the Cdc42-associated kinase to regulate the degradation of epidermal growth factor receptor protein.

From the laboratory of Carl P. Blobel, MD, PhD, Hospital for Special Surgery.

The Investigator's Annexe Part of The Investigator's Annexe program.

Catalog Number Product Size AVAILABILITY Price Qty
EHS013
Anti-SNX9, Cytoplasmic Domain Antibody, 100uL
100uL In stock
Price: $299.00
Specifications
Product Type: Antibody
Antigen: SNX9
Isotype: IgG
Clonality: Polyclonal
Reactivity: Mouse
Immunogen: GST fusion protein with amino acids 6-595 of SNX9
Species Immunized: Rabbit
Purification Method: Serum, not purified
Tested Applications: WB (1:1000)
Storage: -80C
Shipped: Dry ice
Research
Antibody Species Reactivity Specificity
ADAM9 Human Cytoplasmic Domain
ADAM9 Mouse Cytoplasmic Domain
ADAM12 Mouse Cytoplasmic Domain
ADAM15 Human Cytoplasmic Domain
ADAM15 Mouse Cytoplasmic Domain
ADAM15 Human Extracellular Domain
ADAM15 Mouse Disintegrin Domain
ADAM17 Mouse Cytoplasmic Domain
ADAM17 Mouse Pro domain
ADAM19 Mouse Cytoplasmic Domain
ADAM28 Mouse Cytoplasmic Domain
ADAM28 Mouse Extracellular Domain
SNX9 Mouse Cytoplasmic Domain
Data

Western Blot Analysis

A Western blot analysis of cell lysates from transformed primary human embryonal kidney cells (293), HeLa cells, control transfected COS-7 cells, or COS-7 cells transfected with full-length SNX9 (SH3PX1). Blots were probed with rabbit polyclonal SNX9 Antibody or with a preimmune antiserum.

Adapted from: Howard L, et al. Biochem J. 2000, 348, 21-27.

Provider
From the laboratory of Carl P. Blobel, MD, PhD, Hospital for Special Surgery.
References
  1. Howard, L., Nelson, K.K., Maciewicz, R.A., and Blobel, C.P. 1999. Interaction of the metalloprotease-disintegrins MDC9 and MDC15 with two SH3 domain-containing proteins, endophilin I and SH3PX1. J. Biol. Chem. 274:31693-31699.

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