Chicken Anti-Mouse Polycystin-1 (PC1), C-Terminal Antibody
This chicken IgY polyclonal antibody was generated against E. coli produced fusion protein (pET28c) and recognizes mouse Polycystin-1 (PC1) cytosolic carboxyl terminus (CC) amino acid residues 4123–4291.
Highlights
- Reacts with mouse PC1
- Suitable for Immunoprecipitation applications
Polycystin-1 (PC1) is the gene product of PKD1 that is mutated in human autosomal dominant polycystic Kidney disease. It is required for tubular morphogenesis and maintenance of the kidney and other organs. PC1 is a 11-transmembrane glycoprotein that is cic-autoproteolytically cleaved at juxtamembrane extracellular GPS/GAIN in vivo, resulting a N-terminal cleavage fragment and a C-terminal cleavage fragment in the kidney and other tissues.
Also available: Rabbit Anti-Mouse Polycystin-1 (PC1), C-Terminal Antibody.
From the laboratory of Feng Qian, PhD, The Johns Hopkins University.
This chicken IgY polyclonal antibody was generated against E. coli produced fusion protein (pET28c) and recognizes mouse Polycystin-1 (PC1) cytosolic carboxyl terminus (CC) amino acid residues 4123–4291.
Highlights
- Reacts with mouse PC1
- Suitable for Immunoprecipitation applications
Polycystin-1 (PC1) is the gene product of PKD1 that is mutated in human autosomal dominant polycystic Kidney disease. It is required for tubular morphogenesis and maintenance of the kidney and other organs. PC1 is a 11-transmembrane glycoprotein that is cic-autoproteolytically cleaved at juxtamembrane extracellular GPS/GAIN in vivo, resulting a N-terminal cleavage fragment and a C-terminal cleavage fragment in the kidney and other tissues.
Also available: Rabbit Anti-Mouse Polycystin-1 (PC1), C-Terminal Antibody.
From the laboratory of Feng Qian, PhD, The Johns Hopkins University.
| Product Type: | Antibody |
| Antigen: | Mouse PC1 cytosolic carboxyl terminus (CC) |
| Accession ID: | P98161, NP_038658 |
| Molecular Weight: | 18 kDa |
| Isotype: | IgY |
| Clonality: | Polyclonal |
| Reactivity: | Mouse |
| Immunogen: | E. coliproduced fusion protein (pET28c) |
| Species Immunized: | Chicken |
| Epitope: | Amino acid residues 4123?4291 |
| Purification Method: | EGGstract IgY Purification System |
| Tested Applications: | While titration is recommended for each tissues for optimization, we suggest to use 2-5 microliter of chicken CC for IP ( for 1 ml protein sample, 1-5 mg/ml) |
| Storage: | -80C |
| Shipped: | Cold Packs (Domestic, Overnight); Dry Ice (International) |
- Yu S, Hackmann K, Gao J, He X, Piontek K, García-González MA, Menezes LF, Xu H, Germino GG, Zuo J, Qian F. Essential role of cleavage of Polycystin-1 at G protein-coupled receptor proteolytic site for kidney tubular structure. Proc Natl Acad Sci U S A. 2007 Nov 20;104(47):18688-93.
If you publish research with this product, please let us know so we can cite your paper.
