This mouse IgG1 kappa monoclonal antiobody was generated against Full-length recombinant BCL-10 protein and recognizes human BCL-10.
BCL-10 is an apoptotic regulatory molecule, of approximately 31 kDa. It was identified through its direct involvement in t(1:14) (p22;q32) of mucosa-associated lymphoid tissue (MALT) lymphoma. In B-cell follicles, BCL10 has been shown to be expressed abundantly in the germinal center B cells, moderately in the marginal zone, but only weakly in mantle zone B cells. This differential expression is an indicator of its importance in maturation and malignant transformation of human B-cells. BCL-10 contains a caspase recruitment domain (CARD), and has been shown to induce apoptosis and to activate NF-kappaB.
From a laboratory at Cancer Research Technology.
Part of The Investigator's Annexe program.
|Immunogen:||Full-length recombinant BCL-10 protein|
|Tested Applications:||ELISA IHC WB|
|Comments:||IHC-P: 1/25 - 1/100 in an ABC method. Antibody incubation period of 30 minutes at room temperature is recommended. Perform heat mediated antigen retrieval with 10mM citrate buffer, pH 6.0 before commencing with IHC staining protocol.|
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