Anti-Bcl10 [151] Antibody

This mouse IgG1 kappa monoclonal antiobody was generated against Full-length recombinant BCL-10 protein and recognizes human BCL-10.

BCL-10 is an apoptotic regulatory molecule, of approximately 31 kDa. It was identified through its direct involvement in t(1:14) (p22;q32) of mucosa-associated lymphoid tissue (MALT) lymphoma. In B-cell follicles, BCL10 has been shown to be expressed abundantly in the germinal center B cells, moderately in the marginal zone, but only weakly in mantle zone B cells. This differential expression is an indicator of its importance in maturation and malignant transformation of human B-cells. BCL-10 contains a caspase recruitment domain (CARD), and has been shown to induce apoptosis and to activate NF-kappaB.

From a laboratory at Cancer Research Technology.

The Investigator's Annexe Part of The Investigator's Annexe program.

Catalog Number Product Size AVAILABILITY Price Qty
EW2022
Anti-Bcl10 [151] Antibody
100ug 2-3 weeks
Regular Price:$321.00
Specifications

Product Type: Antibody
Antigen: Bcl10
Strain: Balb/c
Isotype: IgG1k
Clone Name: 151
Reactivity: Human
Immunogen: Full-length recombinant BCL-10 protein
Myeloma Used: NSO
Tested Applications: ELISA IHC WB
Comments: IHC-P: 1/25 - 1/100 in an ABC method. Antibody incubation period of 30 minutes at room temperature is recommended. Perform heat mediated antigen retrieval with 10mM citrate buffer, pH 6.0 before commencing with IHC staining protocol.
Storage: -20C
Shipped: Cold Pack

Provider
From a laboratory at Cancer Research Technology.
References
  1. Ye et al. 2000. Am J Pathol. 157:1147-54. PMID: 11021819.
  2. Du et al. 2000. Blood. 95:3885-90. PMID: 10845924.
  3. Shen L et al, Blood. 2003 Aug 15;102(4):1553-4. PMID: 12900354.

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