Anti-Tau [PC1C6] Antibody

This IgG2a mouse antibody was generated against purified denatured bovine microtubule associated proteins (MAPs) and recognizes human, rat, and bovine Tau1.

Highlights:

  • Reacts with human, rat, and bovine Tau1
  • Suitable for Western Blot and Immunohistochemistry applications

Recombinant versions available at our sister company, Absolute Antibody:

Tau protein is a highly soluble microtubule-associated protein. In humans, these proteins are mostly found in neurons compared to non-neuronal cells. One of tau's main functions is to modulate the stability of axonal microtubules. The protein interacts with tubulin to stabilize microtubules and promote tubulin assembly into microtubules. When tau proteins are defective, and no longer stabilize microtubules properly, they can result in dementias such as Alzheimer's disease.

From the laboratory of Lester I. Binder, PhD, University of Virginia.

Catalog Number Product Size AVAILABILITY Price Qty
EG7001
Anti-Tau [PC1C6] Antibody
100ug 2-3 weeks
Regular Price:$377.00
Specifications

Product Type: Antibody
Antigen: Anti-Tau Monoclonal Antibody (PC1C6)
Isotype: IgG2a
Clonality: Monoclonal
Clone Name: PC1C6
Reactivity: Recognizes human, rat, and bovine Tau1
Immunogen: Generated against purified denatured bovine microtubule associated proteins
Species Immunized: balb/c mouse
Purification Method: Protein G affinity purified
Tested Applications: WB,IHC
Concentration: 1 mg/mL
Storage: -20C
Shipped: Cold packs

Data

Specificity of Tau-1 in whole rat brain.

Specificity of Tau-1 in whole rat brain.

Lane A, Coomassie Blue stain of an SDS extract of whole rat brain. Lane B, immunoblot of a lower concentration of the sample in lane A reacted with the Tau-1 monoclonal antibody. Unlike bovine brain, rat brain contains at least six immunoreactive species of tau. Lane C, immunobtot of a twice-cycled microtubule preparation from whole rat brain. Note that two or three polypeptides(*) are lost during microtubule purification. The numbers to the left represent molecularweight (Xl0^-3). (Adapted from: Binder LI, Frankfurter A, and Rebhun LI. The distribution of Tau in mammalian central nervous system. J Cell Biol. 101(4):1371-8 (1985).).

Provider
From the laboratory of Lester I. Binder, PhD, University of Virginia.
References
  1. Binder LI, Frankfurter A, and Rebhun LI. The distribution of Tau in mammalian central nervous system. J Cell Biol. 101(4):1371-8 (1985).

If you publish research with this product, please let us know so we can cite your paper.

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