Anti-Detyrosinated Alpha Tubulin [AA12] Antibody

This IgG2a mouse antibody was generated against alpha tubulin (GEEEGE) and recognizes all mammalian homologs as well as detyrosinated alpha tubulin, a post-translational modification of alpha tubulin.

Highlights:

  • Reacts with alpha tubulin
  • Suitable for Western Blot, Immunoprecipitation, Immunohistochemistry and Immunofluorescence applications

Recombinant versions available at our sister company, Absolute Antibody:

Microtubules are required for many well characterized functions in eukaryotic cells, including the movement of chromosomes in mitosis and meiosis, intracellular transport, establishment and maintenance of cellular morphology, cell growth, cell migration and morphogenesis in multicellular organisms. The building block of a microtubule is the tubulin subunit, a heterodimer of alpha and beta tubulin. Both of these monomers are found in all eukaryotes, and their sequences are highly conserved. The tubulin protein is a major target of drug molecules, and consequently, tubulin inhibitors have attracted great attention as antimitotic antitumor agents for chemotherapeutic use.

From the laboratories of Anthony Frankfurter, PhD and Anthony Spano, PhD, University of Virginia.

The Investigator's AnnexePart of The Investigator's Annexe program.

Catalog Number Product Size AVAILABILITY Price Qty
EG0039
Anti-Detyrosinated Alpha Tubulin [AA12] Antibody
100ug In stock
Regular Price:$328.00
Specifications

Product Type: Antibody
Name: Anti-Detyrosinated Alpha Tubulin (AA12)
Host: balb/c mouse
Isotype: IgG2a
Clonality: Monoclonal
Clone Name: AA12
Specificity: Alpha Tubulin (all mammalian homologs)
Immunogen: Generated against alpha tubulin (GEEEGE)
Format: Liquid
Purity: Protein G affinity purified
Tested Applications: WB (1:1000), IHC, IP, IF (1:500)
Concentration: 1mg/mL
Amount: 100uL
Storage: Store at -20C
Shipped: Cold packs

Provider
From the laboratories of Anthony Frankfurter, PhD and Anthony Spano, PhD, University of Virginia.
References
  1. Esteve MA, Carre M, Bourgarel-Rey V, Kruczynski A, Raspaglio G, Ferlini C, Braguer D. Bcl-2 down-regulation and tubulin subtyppe composition are involved in resistance of ovarian cancer cells to vinflunine. Mol Cancer Ther. 5(11):2824-2833, (2006).

If you publish research with this product, please let us know so we can cite your paper.

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