This mouse IgG1 monoclonal antibody was generated against H-2Kk, and recognizes mouse H2Kk MHC Class I.
MHC Class I H-2 Kk is involved in the presentation of foreign antigens to the immune system. The “classical” MHC Class I molecules are histocompatibility antigens encoded by the H-2 gene complex and consist of heterodimers of highly polymorphic alpha chains noncovalently associated with the invariant Beta2-microglobulin. These antigens are expressed on most nucleated cells, but expression varies on different cell types. MHC Class I molecules present intracellular processed peptides to CD8+ T lymphocytes, which are usually cytotoxic T cells. This results in a cytoxic effector response against the presenting cell. Additionally, MHC Class I antigens are expressed on thymic epithelial cells, which is an important regulation step during the positive and negative selection of CD8+ T cells during T cell ontogeny.
From a laboratory at University of Chicago.
Part of The Investigator's Annexe program.
|Name:||Anti-Mouse H-2Kk MHC Class I (AF3-12.1.3)|
|Specificity:||This antibody recognizes mouse H-2Kk MHC Class I|
|Purity:||Protein G purified|
|Tested Applications:||Immunofluorescence, flow cytometry|
|Storage:||Store at 4C|
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