Anti-MHC Class I H2 Kk [AF3-12.1.3] Antibody

This mouse IgG1 monoclonal antibody was generated against H-2Kk, and recognizes mouse H2Kk MHC Class I.

MHC Class I H-2 Kk is involved in the presentation of foreign antigens to the immune system. The “classical” MHC Class I molecules are histocompatibility antigens encoded by the H-2 gene complex and consist of heterodimers of highly polymorphic alpha chains noncovalently associated with the invariant Beta2-microglobulin. These antigens are expressed on most nucleated cells, but expression varies on different cell types. MHC Class I molecules present intracellular processed peptides to CD8+ T lymphocytes, which are usually cytotoxic T cells. This results in a cytoxic effector response against the presenting cell. Additionally, MHC Class I antigens are expressed on thymic epithelial cells, which is an important regulation step during the positive and negative selection of CD8+ T cells during T cell ontogeny.

From a laboratory at University of Chicago.

The Investigator's Annexe Part of The Investigator's Annexe program.

Catalog Number Product Size AVAILABILITY Price Qty
EZ1001
Anti-MHC Class I H2 Kk [AF3-12.1.3] Antibody
100ug at 1mg/mL 2-3 weeks
Regular Price:$292.00
Specifications

Product Type: Antibody
Name: Anti-Mouse H-2Kk MHC Class I (AF3-12.1.3)
Host: Mouse
Isotype: IgG1
Clonality: Monoclonal
Clone Name: AF3-12.1.3
Specificity: This antibody recognizes mouse H-2Kk MHC Class I
Immunogen: H-2Kk
Format: Liquid
Purity: Protein G purified
Tested Applications: Immunofluorescence, flow cytometry
Concentration: 1mg/mL
Amount: 100uL
Storage: Store at 4C
Shipped: Cold packs

Provider
From a laboratory at University of Chicago.
References
  1. Burrows, G.G., et al. Variation in H-2Kk Peptide Motif Revealed by Sequencing Naturally Processed Peptides Form T-Cell Hybridoma Class I Molecules. Journal of Neuroscience Research. 45: 803 - 811. 1996.

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