Anti-Biglycan (Mouse/Rat) [LF-159] Antibody
![Anti-Biglycan [LF-159] Antibody](https://www.kerafast.com/MediaStorage/Product/Images/Large/1381_2001202001264513800.jpg "Anti-Biglycan (Mouse/Rat) [LF-159] Antibody")
This rabbit IgG polyclonal antibody was raised against peptide and recognizes mouse and rat biglycan.
Highlights:
- Recognizes mouse and rat biglycan - Epitope -amino acid sequence VPDLDSVTPTFSAMC
- Suitable for Immunohistochemistry and Western Blot applications
Biglycan is a small leucine-rich repeat proteoglycan (SLRP) which is found in a variety of extracellular matrix tissues, including bone, cartilage and tendon. In humans it is encoded by the BGN gene located on the X chromosome and is mainly involved in collagen fiber assembly.
From the laboratory of Larry W. Fisher, PhD, National Institute of Dental and Craniofacial Research/NIH.
This rabbit IgG polyclonal antibody was raised against peptide and recognizes mouse and rat biglycan.
Highlights:
- Recognizes mouse and rat biglycan - Epitope -amino acid sequence VPDLDSVTPTFSAMC
- Suitable for Immunohistochemistry and Western Blot applications
Biglycan is a small leucine-rich repeat proteoglycan (SLRP) which is found in a variety of extracellular matrix tissues, including bone, cartilage and tendon. In humans it is encoded by the BGN gene located on the X chromosome and is mainly involved in collagen fiber assembly.
From the laboratory of Larry W. Fisher, PhD, National Institute of Dental and Craniofacial Research/NIH.
This product is for sale to Nonprofit customers only. For profit customers, please Contact Us for more information.
Specifications
| Product Type: | Antibody |
| Alternative Name(s): | Bone/cartilage proteoglycan I, PG-S1 |
| Antigen: | Biglycan |
| Accession ID: | P21810 |
| Molecular Weight: | 39871 Da |
| Isotype: | IgG |
| Clonality: | Polyclonal |
| Clone Name: | LF-159 |
| Reactivity: | Mouse and Rat |
| Immunogen: | Peptide |
| Species Immunized: | Rabbit |
| Epitope: | VPDLDSVTPTFSAMC |
| Buffer: | Whole serum |
| Tested Applications: | WB (1:1000), IHC (1:200) |
| Storage: | -80C |
| Shipped: | Cold Packs (Domestic, Overnight); Dry Ice (International) |
Provider
From the laboratory of Larry W. Fisher, PhD, National Institute of Dental and Craniofacial Research/NIH.
References
- Fisher LW, Stubbs JT 3rd, Young MF. Antisera and cDNA probes to human and certain animal model bone matrix noncollagenous proteins. Acta Orthop Scand Suppl. 1995 Oct;266:61-5.
- von Marschall Z, Fisher LW. Decorin is processed by three isoforms of bone morphogenetic protein-1 (BMP1). Biochem Biophys Res Commun. 2010 Jan 15;391(3):1374-8. doi: 10.1016/j.bbrc.2009.12.067.
- Fust A, LeBellego F, Iozzo RV, Roughley PJ, Ludwig MS. Alterations in lung mechanics in decorin-deficient mice. Am J Physiol Lung Cell Mol Physiol. 2005 Jan;288(1):L159-66.
- Chan WL, Steiner M, Witkos T, Egerer J, Busse B, Mizumoto S, Pestka JM, Zhang H, Hausser I, Khayal LA, Ott CE, Kolanczyk M, Willie B, Schinke T, Paganini C, Rossi A, Sugahara K, Amling M, Knaus P, Chan D, Lowe M, Mundlos S, Kornak U. Impaired proteoglycan glycosylation, elevated TGF-β signaling, and abnormal osteoblast differentiation as the basis for bone fragility in a mouse model for gerodermia osteodysplastica. PLoS Genet. 2018 Mar 21;14(3):e1007242. View Article
- Li C, Jing Y, Wang K, Ren Y, Liu X, Wang X, Wang Z, Zhao H, Feng JQ. Dentinal mineralization is not limited in the mineralization front but occurs along with the entire odontoblast process. Int J Biol Sci. 2018 Apr 30;14(7):693-704. View Article
- Hua R, Ni Q, Eliason TD, Han Y, Gu S, Nicolella DP, Wang X, Jiang JX. Biglycan and chondroitin sulfate play pivotal roles in bone toughness via retaining bound water in bone mineral matrix. Matrix Biol. 2020 Sep 28:S0945-053X(20)30089-5. View article
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