Thomas R. Malek, PhD, University of Miami
Thomas R. Malek, PhD
The Malek laboratory research focus is to better define the mechanisms by which regulatory T cells (Tregs) contribute to self-tolerance, with a focus on the role of IL-2R signaling. Mouse models are used to establish the relevance and inter-relationships of Treg heterogeneity to support self-tolerance and to define the role of IL-2R signaling in the development and homeostasis of Treg subsets.
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References
- Malek TR, Furse RK, Fleming ML, Fadell AJ, He YW. Biochemical identity and characterization of the mouse interleukin-2 receptor beta and gamma c subunits. J Interferon Cytokine Res. 1995 May;15(5):447-54. PubMed PMID: 7648447.
- Jin H, Carrio R, Yu A, Malek TR. Distinct activation signals determine whether IL-21 induces B cell costimulation, growth arrest, or Bim-dependent apoptosis. J Immunol. 2004 Jul 1;173(1):657-65. PubMed PMID: 15210829.
