Jeremy Nathans, MD, PhD, The Johns Hopkins University

Jeremy Nathans, MD, PhD
Jeremy Nathans, MD, PhD

The Nathans laboratory is focused on several broad and related areas of research: (1) neural and vascular development, and (2) the role of Frizzled receptors in mammalian development. They use gene manipulation in the mouse, cell culture models, and biochemical reconstitution to investigate the relevant molecular events underlying these processes, and to genetically mark and manipulate cells and tissues.

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References

  1. Nathans J, Thomas D, Hogness DS. Molecular genetics of human color vision: the genes encoding blue, green, and red pigments. Science. 1986 Apr 11;232(4747):193-202. PubMed PMID: 2937147.
  2. Zhou Y, Williams J, Smallwood PM, Nathans J. Sox7, Sox17, and Sox18 Cooperatively Regulate Vascular Development in the Mouse Retina. PLoS One. 2015 Dec 2;10(12):e0143650.
  3. Luo W, Williams J, Smallwood PM, Touchman JW, Roman LM, Nathans J. Proximal and distal sequences control UV cone pigment gene expression in transgenic zebrafish. J Biol Chem. 2004 Apr 30;279(18):19286-93
  4. Xu Q, Wang Y, Dabdoub A, Smallwood PM, Williams J, Woods C, Kelley MW, Jiang L, Tasman W, Zhang K, Nathans J. Vascular development in the retina and inner ear: control by Norrin and Frizzled-4, a high-affinity ligand-receptor pair. Cell. 2004 Mar 19;116(6):883-95.