Mark S. Parcells, PhD, University of Delaware

Mark S. Parcells, PhD
Mark S. Parcells, PhD

Dr. Parcells studies the function of genes encoded by Marek's Disease Virus (MDV), a T-lymphoma-inducing herpesvirus of chickens. The projects in his laboratory range from the functional interactions of viral and cellular proteins as they relate to MDV infection and pathogenesis, the evolution of MDV virulence, to the development and testing of vaccines for Marek's disease. Dr. Parcells has a strong interest in tumor immunology and tumor virology and vaccine development.

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References

  1. Dienglewicz, RL and MS Parcells. 1999. Establishment of a lymphoblastoid cell line using a mutant MDV containing a green fluorescent protein expression cassette. Acta Virol. 43:106-1112.
  2. Hunt, HD, B Lupiani, MM Miller, I Gimeno, LF Lee and MS. Parcells. 2001. Marek's disease virus down-regulates surface expression of MHC (B Complex) Class I (BF) glycoproteins during active but not latent infection of chicken cells. Virology 282:198-205.
  3. Prigge, JT, V. Majerciak, HD Hunt, RL Dienglewicz, and MS Parcells. 2004. Construction and characterization of Marek's disease viruses having green fluorescent protein expression tied directly or indirectly to phosphoprotein 38 expression. Avian Diseases 48:471-487.
  4. Santin, E, CE Shamblin, JT Prigge, V Arumugaswami, RL Dienglewicz, and MS Parcells. 2006. Examination of the effect of a naturally occurring mutation in glycoprotein L on the MarekÂ?s disease virus pathogenesis. Avian Dis. 50:96-103.
  5. Parcells, MS, RL Dienglewicz, AS Anderson, and RW Morgan. 1999. Recombinant Marek's disease viruses (MDV)-derived lymphoblasoid cell lines: regulation of a marker gene in the context of the MDV genome.
  6. Parcells, MS and SC Burgess. 2008. Immunological aspects of MarekÂ?s disease virus (MDV)-induced lymphoma progression. Chapter 8 in Selected Aspects of Cancer Progression: Metastasis, Apoptosis and Immune Response. H.E. Kaiser and A. Nasir, Eds. Springer Science and Business Media. P.169 Â? 191.
  7. Kumar, P, H Dong, D Lenihan, S Gaddamanugu, U Katneni, S Shaikh, P Tavlarides-Hontz, SM Reddy, W Peters, and MS Parcells. 2012. Selection of a recombinant Marek's disease virus in vivo through expression of the Marek's EcoRI-Q (Meq)-encoded oncoprotein: characterization of an rMd5-based mutant expressing the Meq of strain of RB-1B. Avian Dis. 56:328-340.