Lance Wells, PhD, University of Georgia

Lance Wells, PhD
Lance Wells, PhD

Using a combination of methodologies, including mass spectrometry, protein biochemistry, cell biology, genetics, proteomics, and molecular biology, the Wells laboratory studies the role of PTMs (primarily O-glycosylation) in a variety of pathophysiological processes including cancer, diabetes, viral infection, neurological disorders, and congenital muscular dystrophy. Their research is aimed at increasing our understanding of how increased functional diversity leads to finer control of biological processes. The hope is that by understanding the role of PTMs, they will not only more accurately describe fundamental biological processes but will also elucidate novel therapeutic targets in disease states where these processes have become dysregulated.

See Also: UGA Complex Carbohydrate Research Center (CCRC)

 

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References

  1. Chin Fen Teo, Sampat Ingale, Margreet A. Wolfert, Galal A. Elsayed, Laszlo G. Nöt, John C. Chatham, Lance Wells, and Geert-Jan Boons: Glycopeptide specific monoclonal antibodies suggest new roles for O-GlcNAc. Nat Chem Biol. 2010 May ; 6(5): 338â??343. doi:10.1038/nchembio.338