Wei Hsu, PhD, University of Rochester

Wei Hsu, PhD
Wei Hsu, PhD

The Hsu laboratory focuses on the global objectives of understanding how embryos develop from a single cell to a complex organism, how genes control the development of organs, and how abnormal regulation of these genes resulted in human diseases. They are investigating the genetic control of cellular signaling and signal transduction mechanisms. By delineating these regulatory networks underlying normal developmental processes, they hope to advance the knowledge base of human diseases, leading to novel molecular therapies for the treatment of these diseases. To achieve their goals, they are focusing on (1) characterizing morphogenetic signaling pathways that regulate mammalian development (specifically wnt-axin pathway), (2) elucidating the mechanism by which these developmental signals regulate cell growth, differentiation and survival, and (3) creating mouse models to study the molecular basis of human diseases.

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References

  1. Fu J, Jiang M, Mirando AJ, Yu HM, Hsu W. "Reciprocal regulation of Wnt and Gpr177/mouse Wntless is required for embryonic axis formation." Proceedings of the National Academy of Sciences of the United States of America. 2009 Nov 3; 106(44):18598-603.
  2. Yu HM, Jin Y, Fu J, Hsu W. "Expression of Gpr177, a Wnt trafficking regulator, in mouse embryogenesis." Developmental dynamics : an official publication of the American Association of Anatomists. 2010 Jul; 239(7):2102-9.
  3. Fu J, Ivy Yu HM, Maruyama T, Mirando AJ, Hsu W. "Gpr177/mouse Wntless is essential for Wnt-mediated craniofacial and brain development." Developmental dynamics : an official publication of the American Association of Anatomists. 2011 Feb; 240(2):365-71. Epub 2011 Jan 11.
  4. Fu J, Hsu W. "Epidermal Wnt controls hair follicle induction by orchestrating dynamic signaling crosstalk between the epidermis and dermis." The Journal of investigative dermatology. 2013 Apr; 133(4):890-8.
  5. Maruyama T, Jiang M, Hsu W. "Gpr177, a novel locus for bone mineral density and osteoporosis, regulates osteogenesis and chondrogenesis in skeletal development." Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 2013 May; 28(5):1150-9.
  6. Maruyama EO, Yu HM, Jiang M, Fu J, Hsu W. "Gpr177 deficiency impairs mammary development and prohibits Wnt-induced tumorigenesis." PloS one. 2013 8(2):e56644.
  7. Zhu X, Zhao P, Liu Y, Zhang X, Fu J, Yu HM, Qiu M, Chen Y, Hsu W, Zhang Z. "Intra-epithelial requirement of canonical Wnt signaling for tooth morphogenesis." The Journal of biological chemistry. 2013 Apr 26; 288(17):12080-9.
  8. Zhu XJ, Liu Y, Dai ZM, Zhang X, Yang X, Li Y, Qiu M, Fu J, Hsu W, Chen Y, Zhang Z. "BMP-FGF signaling axis mediates Wnt-induced epidermal stratification in developing mammalian skin." PLoS genetics. 2014 Oct; 10(10):e1004687.
  9. Jiang, M., S.Y. Chiu, and W. Hsu, SUMO-specific protease 2 in Mdm2-mediated regulation of p53. Cell Death Differ, 2011. 18(6): p. 1005-15.
  10. Chiu, S.Y., N. Asai, F. Costantini, and W. Hsu, SUMO-Specific Protease 2 Is Essential for Modulating p53-Mdm2 in Development of Trophoblast Stem Cell Niches and Lineages. PLoS Biol, 2008. 6(12): p. e310.
  11. Fu, J., H.M. Yu, S.Y. Chiu, A.J. Mirando, E.O. Maruyama, J.G. Cheng, and W. Hsu, Disruption of SUMO-Specific Protease 2 Induces Mitochondria Mediated Neurodegeneration. PLoS Genet, 2014. 10(10): p. e1004579.