Philip M. Carpenter, MD, University of Southern California

Philip M. Carpenter, MD
Philip M. Carpenter, MD

The Carpenter laboratory is interested in the role of normal tissue in promoting metastasis, the spread of tumor tissue throughout the body. Their studies focus on how this tumor cell movement may be induced by secretion of factors from the nearby normal tissue. They have learned that in the initial invasion step, normal mammary duct cells secrete a factor that increases the migratory ability of MCF-7 breast cancer cells. Currently, they investigating the nature of this mammary motility factor and have recently developed an assay to study tumor cell movement into vascular-like structures.

The Investigator's Annexe Part of The Investigator's Annexe program.

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References

  1. Aumailley M, Bruckner-Tuderman L, Carter WG, et al. A simplified laminin nomenclature. Matrix Biol. 2005;24(5):326-332.
  2. Goldfinger LE, Hopkinson SB, deHart GW, Collawn S, Couchman JR, Jones JC. The 3 laminin subunit, alpha-6-beta-4 and alpha-3-beta-1 integrin coordinately regulate wound healing in cultured epithelial cells and in the skin. J Cell Sci. 1999;112(Pt 16):2615-2629.
  3. Patarroyo M, Tryggvason K, Virtanen I. Laminin isoforms in tumor invasion, angiogenesis and metastasis. Semin Cancer Biol 2002;12(3):197-207
  4. Carpenter PM, Dao AV, Arain ZS, et al. Motility induction in breast carcinoma by mammary epithelial laminin 332 (laminin 5). Mol Cancer Res. 2009;7(4):462-75.
  5. Guess CM, Quaranta V. Defining the role of laminin-332 in carcinoma. Matrix Biol. 2009;28(8):445-55.