COVID-19/SARS-CoV Nucleoprotein [CR3018 (03-018)] Antibodies
![Anti-COVID-19/SARS-CoV Nucleoprotein [CR3018 (03-018)] Human IgG1k Antibody](https://www.kerafast.com/MediaStorage/Product/Images/Large/1046_2001202001263210450.jpg "Anti-COVID-19/SARS-CoV Nucleoprotein [CR3018 (03-018)] Human IgG1k Antibody")
Recombinant monoclonal antibody to COVID-19 & SARS-CoV Nucleoprotein.
Highlights:
- Choose from human IgG1 or rabbit IgGk formats
- Manufactured using Absolute Antibody’s Recombinant Platform with variable regions (i.e., specificity) from the hybridoma CR3018
- Chimeric rabbit antibody was made using the variable domain sequences of the original Human IgG1 format, for improved compatibility with existing reagents, assays and techniques
From our sister company Absolute Antibody.
Recombinant monoclonal antibody to COVID-19 & SARS-CoV Nucleoprotein.
Highlights:
- Choose from human IgG1 or rabbit IgGk formats
- Manufactured using Absolute Antibody’s Recombinant Platform with variable regions (i.e., specificity) from the hybridoma CR3018
- Chimeric rabbit antibody was made using the variable domain sequences of the original Human IgG1 format, for improved compatibility with existing reagents, assays and techniques
From our sister company Absolute Antibody.
| Catalog Number | Product | DataSheet | Size | AVAILABILITY | Price | Qty |
|---|
For larger sizes, please Contact Us for a bulk discount.
Specifications
| Product Type: | Antibody |
| Name: | Anti-COVID-19/SARS-CoV Nucleoprotein [CR3018 (03-018)] |
| Alternative Name(s): | NP; NC; Protein N; Nucleocapsid protein; SARS-CoV Protein N; SARS-CoV Nucleocapsid protein; SARS Coronavirus; SARS-CoV-2; SARS CoV 2; 2019-nCoV |
| Antigen: | COVID-19/SARS-CoV Nucleoprotein |
| Accession ID: | P0DTC9 |
| Source: | Recombinant |
| Isotype: | Human IgG1k or Rabbit IgGk |
| Clonality: | Monoclonal |
| Clone Name: | CR3018 (03-018) |
| Reactivity: | SARS-CoV-2 (COVID-19) and SARS Coronavirus |
| Specificity: | This antibody binds the amino acid residues between 11-19 of the N protein of the SARS CoV as well as SARS-CoV-2 (COVID-19) nucleocapsid protein. |
| Immunogen: | The original antibody was generated by cloning the variable regions of the scFvs selected from phage display libraries into separate vectors for IgG1 heavy-chain and light-chain expression. The harvested supernatents were then purified on protein A columns. |
| Epitope: | aa 11-19 of Nucleoprotein |
| Purification Method: | Protein A |
| Buffer: | PBS, 0.02% Proclin 300 |
| Tested Applications: | ELISA, IF |
| Concentration: | 1 mg/mL |
| Storage: | Store at +4C for up to 3 months. For longer storage, aliquot and store at -20C. |
| Shipped: | Cold packs |
Provider
From our sister company Absolute Antibody.
Comments
This antibody is recommended for detection of SARS CoV2 protein N (nucleoprotein). This antibody binds both the nucleocapsid protein of the SARS-CoV and SARS CoV-2 (2019-nCoV). Initial characterization of the antibody for binding to 2019-nCoV was done using ELISA. This antibody shows potential to be used for development of diagnostic assays. Various isotype versions of the antibody namely human IgG1, IgG3, IgM, IgA and the less common IgG2 and IgG4 are available for the investigation of their role in response to SARS CoV2. Competitive ELISA of this antibody with CR3009 suggests that both these antibodies bind different epitopes of the N protein of SARS CoV. Thus, a combination of these two antibodies is suggested for virus capture assays. Immunofluorescence staining was used to demonstrate binding of CR3018 to SARS-CoV infected Vero cells. (PMID:15650189).
References
- van den Brink EN, Ter Meulen J, Cox F, et al. Molecular and biological characterization of human monoclonal antibodies binding to the spike and nucleocapsid proteins of severe acute respiratory syndrome coronavirus. J Virol. 2005;79(3):1635_1644.
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