Human Complement Protein FHR-3 (CFHR3) Antibodies
![Anti-Complement FHR-3 (CFRH3) [18A7] Antibody](https://www.kerafast.com/MediaStorage/Product/Images/Large/1046_2001202001263210450.jpg "Anti-Complement FHR-3 (CFRH3) [18A7] Antibody")
These mouse IgG1k monoclonal antibodies were raised against recombinant human complement factor H-related protein-3 (FHR-3) and recognize human FHR-3.
Highlights:
- React with human FHR-3
- 18A7 Binds to the SCR4-5 domain; No cross-reactivity with CFH and CFH-related proteins
- 19E9 Binds to the SCR1-3 domain; cross-reacts with CFH
- 18H8 Binds to CFHR3; No cross-reactivity with CFH and CFH-related proteins
- Suitable ELISA and Immunoblot applications
The protein encoded by this gene is a secreted protein, which belongs to the complement factor H-related protein family. It binds to heparin, and may be involved in complement regulation. Mutations in this gene are associated with decreased risk of age-related macular degeneration, and with an increased risk of atypical hemolytic-uremic syndrome.
From a laboratory at University of Göttingen.
These mouse IgG1k monoclonal antibodies were raised against recombinant human complement factor H-related protein-3 (FHR-3) and recognize human FHR-3.
Highlights:
- React with human FHR-3
- 18A7 Binds to the SCR4-5 domain; No cross-reactivity with CFH and CFH-related proteins
- 19E9 Binds to the SCR1-3 domain; cross-reacts with CFH
- 18H8 Binds to CFHR3; No cross-reactivity with CFH and CFH-related proteins
- Suitable ELISA and Immunoblot applications
The protein encoded by this gene is a secreted protein, which belongs to the complement factor H-related protein family. It binds to heparin, and may be involved in complement regulation. Mutations in this gene are associated with decreased risk of age-related macular degeneration, and with an increased risk of atypical hemolytic-uremic syndrome.
From a laboratory at University of Göttingen.
| Catalog Number | Product | DataSheet | Size | AVAILABILITY | Price | Qty |
|---|
Specifications
| Product Type: | Antibody |
| Antigen: | Human FHR-3 |
| Accession ID: | Q02985 |
| Isotype: | IgG1k |
| Clonality: | Monoclonal |
| Reactivity: | Human |
| Immunogen: | Recombinant human complement protein FHR-3 |
| Species Immunized: | Mouse |
| Myeloma Used: | X63-Ag8.653 |
| Epitope: | 18A7: SCR4-5 domain; 19E9: SCR1-3 domain; 18H8: unknown |
| Purification Method: | Protein G |
| Buffer: | PBS, 0.05% (w/v) Sodium Azide |
| Tested Applications: | ELISA and Immunoblot |
| Storage: | -20C |
| Shipped: | Cold packs |
Data
Western Blot for FHR-3
Provider
From a laboratory at University of Göttingen.
Comments
18H8: Can be used for FHR-3 detection in human plasma by immunoblotting
18A7: Capture antibody in FHR-3 ELISA (together with 19E9)
19E9: Detecting antibody in FHR-3 ELISA (together with 18A7)
18A7: Capture antibody in FHR-3 ELISA (together with 19E9)
19E9: Detecting antibody in FHR-3 ELISA (together with 18A7)
References
- Fritsche LG, Lauer N, Hartmann A, et al. An imbalance of human complement regulatory proteins CFHR1, CFHR3 and factor H influences risk for age-related macular degeneration (AMD). Hum Mol Genet. 2010;19(23):4694-4704. doi:10.1093/hmg/ddq399
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