Phloridzin Dihydrate is a dihydrochalcone produced from apple wood, which reduces blood glucose levels and may be a natural anti-diabetic molecule.
Dietary consumption of Phloridzin has been shown to reduce blood glucose levels. Phloridzin is shown to induce experimental glycosuria by blocking the reabsorption of glucose from the kidney. The anti-diabetic action is through the competitive inhibition of the sodium-dependent blood transporters (SGLT1 and SGLT2) of metabolites such as glucose. Additionally, Phloridzin activates a cascade of enzymes, including tyrosinase, by blocking the activity of protein kinase C. As a result, it is involved in inhibiting the growth of tumor cells and provides increased protection against ultraviolet radiation through the activation of melanogenesis.
|Product Type:||Small Molecule|
|Chemical Formula:||C21H24O10, 2H2O|
|Format:||White crystalline solid|
|Purity:||>99 % determined by HPLC|
|Solubility:||Soluble in boiling water, methanol, ethanol, acetone, and ethyl acetate.|
|Stability:||Stable when stored at 4C away from oxygen and direct sunlight|
|Storage:||4C, avoid exposure to heat and direct sunlight|
Phloridzin dihydrate HPLC Chromatogram.
Purification Notes: Extracted from apple wood using segmentation chromatography.
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