Nobiletin

Nobiletin is a nonpolar polymethoxylated flavone isolated from the citrus peel shown to have anti-inflammatory, anticancer, and antiatherogenic properties.

Nobiletin can reduce the circulating concentrations of very low-density and low-density lipoproteins, and inhibit macrophage foam-cell formation at the side of lesion development within a vessel wall (thus preventing atherosclerosis). Both nobiletin and tangeretin, isolated from tangerine juice, have been shown to be effective inhibitors of human prostate cancer cells and melanoma cells. It appears that nobiletin induces cell apoptosis, causing cell cycle arrest at the G2/M phase. Additionally, nobiletin effectively interferes with gene expression of aggrecanase-1 and aggrecanase-2, providing evidence that the phytochemical prevents cartilage destruction in collagen-induced arthritis (CIA) mice.

Catalog Number Product DataSheet Size AVAILABILITY Price Qty
FAP051
Nobiletin, 5mg
5mg 1-2 weeks
Regular Price:$220.00
On Sale:
FAP052
Nobiletin, 25mg
25mg 1-2 weeks
Regular Price:$880.00
On Sale:
Specifications

Product Type: Small Molecule
Chemical Formula: C21H22O8
CAS number: 478-01-3
Molecular Weight: 402.4
Format: White to off-white crystalline solid
Purity: >99 % determined by HPLC
Solubility: Soluble in methanol.
Stability: stable over extended period at -20C
Storage: -20C, avoid exposure to oxygen and direct sunlight
Shipped: Cold Pack

Data

Nobiletin HPLC Chromatogram.


Purification Notes: Extracted from Citurs sinensis using supercritical fluid fractionation and then purified using silica and C18 chromatography.

References
  1. Choi S, Hwang J, Ko H, Park J and Kim S. (2007). Nobiletin from citrus fruit peel inhibits the DNA-dinging activity of NF-kappaB and ROS production in LPS-activated RAW 264.7 cells. J Ethnopharmacol. 113: 149-155.
  2. Imada K, Lin N, Liu C, Lu A, Chen W, Yano M, Sato T and Ito A. (2008). Nobiletin, a citrus polymethoxy flavonoid, suppresses gene expression and production of aggrecanases-1 and -2 in collagen-induced arthritic mice. Biochem Biophys Res Commun. 373: 181-185.
  3. Kurowska E and Manthey J. (2004). Hypolipidemic effects and absorption of citrus polymethoxylated flavones in hamsters with diet-induced hypercholesterolemia. J Agric Food Chem. 52: 2879-2886.
  4. Lin N, Sato T, Takayama Y, Mimaki Y, Sashida Y, Yano M and Ito A. (2003). Novel anti-inflammatory actions of nobiletin, a citrus polymethoxy flavonoid, on human synovial fibroblast and mouse macrophages. Biochem Pharmacol. 65: 2065-2071.
  5. Luo G, Guan X and Zhou L. (2008). Apoptotic effect of citrus fruit extract nobiletin on lung cancer cell line A549 in vitro and in vivo. Cancer Biol. Ther 7: 966-973.
  6. Manthey J and Guthrie N. (2002). Antiproliferative activities of citrus flavonoids against six human cancer cell lines. J Agric Food Chem 50: 5837-5843
  7. Whitman S, Kurowska E, Manthey J and Daugherty A. (2005). Nobiletin, a citrus flavonoid isolated from tangerines, selectively inhibits class A scavenger receptor-mediated metabolism of acetylated LDL by mouse macrophages. Atherosclerosis. 178: 25-32.

If you publish research with this product, please let us know so we can cite your paper.

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