Jervine

Jervine is an alkaloid isolated from the corn lily and is an antagonist of the Sonic Hedgehog gene pathway with potential anticancer properties.

Jervine is a potent teratogen that is implicated in birth defects in vertebrates. Its biological activity is mediated by its interaction with the protein Smoothened, which is an integral part of the hedgehog signaling pathway. It inhibits Smoothened and prevents the activation of GLI1 transcription, which in turn inhibits the transcription of hedgehog target genes.

Catalog Number Product Size AVAILABILITY Price Qty
FAP043
Jervine, 1mg
1mg 1-2 weeks
Regular Price:$100.17
FAP044
Jervine, 5mg
5mg 1-2 weeks
Regular Price:$400.67
Specifications

Product Type: Small Molecule
Chemical Formula: C27H39NO3
CAS number: 469-59-0
Molecular Weight: 452.6
Format: White to off-white crystals
Purity: >98 % determined by HPLC
Solubility: Soluble in methanol and ethanol
Stability: Stable over extended period at -20C
Storage: -20C
Shipped: Cold Pack

Comments

Purification Notes: Isolated by near-critical and supercritical fluids in phase extraction followed by segmentation chromatography

References

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