Hyperforin DCHA

Hyperforin and adhyperforin are extracted from the flowers and buds of Hypericum perforatum (St. John's Wort) utilizing the patented SuperFluids CXP technology [Castor, US Patent].

Hyperforin dicyclohexylammonium salt (Hyperforin DCHA) is the salt of Hyperforin, the primary active constituent responsible for the antidepressant and anxiolytic properties of extracts of St. John's Wort. It acts as a reuptake inhibitor of serotonin and other monoamines including norepinephrine, dopamine, and of GABA and glutamate by activating the transient receptor potential ion channel TRPC6. It also is an activator of the pregnane X receptor (PXR), which serves as a key regulator of CYP3A4 transcription, a member of the cytochrome (CYP) P450 enzyme system. Recent studies have found other neurological effects, effects on inflammation, as well as antibacterial, antitumoral and antiangiogenic effects.

Catalog Number Product DataSheet Size AVAILABILITY Price Qty
FAP041
Hyperforin DCHA, 0.5mg
0.5mg 1-2 weeks
Regular Price:$115.00
On Sale:
FAP042
Hyperforin DCHA, 2mg
2mg 1-2 weeks
Regular Price:$465.00
On Sale:
Specifications

Product Type: Small Molecule
Chemical Formula: C35H52O4, C12H23N
CAS number: 238074-03-8
Molecular Weight: 718.1
Format: White to off-white crystalline solid
Purity: >99.5 % determined by HPLC; <0.1 % Adhyperforin by HPLC
Solubility: Soluble in methanol and ethanol
Stability: Samples stored at 5°C, 25°C, and 43°C for 60 days showed no decomposition as indicated by UV absorption or HPLC. Hyperforin DCHA stored at -20°C was stable after 2 years.
Storage: 5C, avoid exposure to direct sunlight
Shipped: Ambient temperature

Data

Hyperforin DCHA HPLC Chromatogram.


Purification Notes: Initial silica chromatography separates oils and polar components from hyperforin and adhyperforin. Then C18 chromatography is used to separate hyperforin and adhyperforin. Hyperforin is in greater quantity and in the reversed phase system, hyperforin leads the adhyperforin. This means that the initial fractions will be hyperforin devoid of adhyperforin, and the later fractions will be adhyperforin contaminated with low levels of hyperforin. Hyperforin is then purified and stabilized by the formation of the dicyclohexylammonium salt.

References
  1. Beerhues L. (2006). Hyperforin. Phytochemistry. 67, 2201-2207.
  2. Cantoni L, Rozio M, Mangolini A, Hauri L and Caccia S. (2003). Hyperforin Contributes to the Hepatic CYP3A-Inducing Effect of Hypericum perforatum Extract in the Mouse. Toxicological Sciences. 75, 25-30.
  3. Cervo L, Rozio M, Ekalle-Soppo C, Guiso G, Morazzoni P and Caccia S. (2002). Role of hyperforin in the antidepressant-like activity of Hypericum perforatum extracts. Psychopharmacology. 164, 423-428.
  4. Linde K, Ramirez G, Murlow C, Pauls A, Weidenhammer W and Melchart D. (1996). St John's wort for depression—an overview and meta-analysis of randomized clinical trials. BMJ. Aug 3; 313(7052):253-258.
  5. Woelk H. (2000). Comparison of St John's wort and imipramine for treating depression: randomized controlled trials. BMJ. 321, 536-539.

If you publish research with this product, please let us know so we can cite your paper.

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