Frondoside A is a triterpenoid saponin isolated from the sea cucumber Cucumaria frondosa with potential anticancer properties.
Frondoside A is of interest as a potential anticancer agent. It has potent cytotoxicity against THP-1 and HeLa tumor cell lines with IC50 values of 4.5 ug/mL and 2.1 ug/mL, respectively. It has been shown to inhibit proliferation and induces apoptosis of human pancreatic cancer xenografts. It has also inhibited the migration and invasion of breast cancer cell line MDA-MB-231 in vitro. Additionally, Frondoside A strongly decreased the growth of MDA-MB-231 tumor xenografts in athymic mice without any toxic side effects. Another study has shown that Frondoside A has potent anti-metastatic activity. The glycoside inhibited tumor metastasis in a murine model of metastatic breast cancer, and its mechanism of action is partially attributed to its ability to antagonize prostaglandin E receptors EP4 and EP2. All these studies support Frondoside A as a promising novel therapeutic cancer agent.
|Product Type:||Small Molecule|
|Format:||White crystalline solid|
|Solubility:||Soluble in water/methanol|
|Stability:||Stable as a solid over extended period at -20C.|
|Storage:||-20C, avoid exposure to oxygen and direct sunlight|
Frondoside A HPLC Chromatogram.
Purification Notes: Purification is conducted using segmentation chromatography following extraction from the sea cucumber.
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