Frondoside A

Frondoside A is a triterpenoid saponin isolated from the sea cucumber Cucumaria frondosa with potential anticancer properties.

Frondoside A is of interest as a potential anticancer agent. It has potent cytotoxicity against THP-1 and HeLa tumor cell lines with IC50 values of 4.5 ug/mL and 2.1 ug/mL, respectively. It has been shown to inhibit proliferation and induces apoptosis of human pancreatic cancer xenografts. It has also inhibited the migration and invasion of breast cancer cell line MDA-MB-231 in vitro. Additionally, Frondoside A strongly decreased the growth of MDA-MB-231 tumor xenografts in athymic mice without any toxic side effects. Another study has shown that Frondoside A has potent anti-metastatic activity. The glycoside inhibited tumor metastasis in a murine model of metastatic breast cancer, and its mechanism of action is partially attributed to its ability to antagonize prostaglandin E receptors EP4 and EP2. All these studies support Frondoside A as a promising novel therapeutic cancer agent.

Catalog Number Product Size AVAILABILITY Price Qty
FAP029
Frondoside A, 1 mg
1mg 1-2 weeks
Regular Price:$214.00
FAP030
Frondoside A, 5mg
5mg 1-2 weeks
Regular Price:$856.00
Specifications

Product Type: Small Molecule
Chemical Formula: C60H96O29SNa
CAS number: 127367-76-4
Molecular Weight: 1336.4
Format: White crystalline solid
Purity: >98 %
Solubility: Soluble in water/methanol
Stability: Stable as a solid over extended period at -20C.
Storage: -20C, avoid exposure to oxygen and direct sunlight
Shipped: Cold Pack

Data

Frondoside A HPLC Chromatogram.


Purification Notes: Purification is conducted using segmentation chromatography following extraction from the sea cucumber.

References
  1. Al Marzouqi N, Iratni R, Nemmar A, Arafat K, Ahmed Al Sultan M, Yasin J, Collin P, Mester J, Adrian T and Attoub S. (2011). Frondoside A inhibits human breast cancer cell survival, migration, invasion and the growth of breast tumor xenografts. Eur J Pharmacol. 668: 25-34.
  2. Li X, Roginsky A, Ding X, Woodward C, Collin P, Newman R, Bell R and Adrian T. (2008). Review of the apoptosis pathways in pancreatic cancer and the anti-apoptotic effects of the novel sea cucumber compound, Frondoside A. Ann N Y Acad Sci. 1138: 181-198.
  3. Ma X, Kundu N, Collin P, Goloubeva O and Fulton A. (2011). Frondoside A inhibits breast cancer metastasis and antagonizes prostaglandin E receptors EP4 and EP2. Breast Cancer Res Treat. DOI: 10.1007/s10549-011-1675-z.
  4. Silchenko A, Avilov S, Kalinin V, Kalinovsky A, Dmitrenok P, Fedorov S, Stepanov V, Dong Z and Stonik V. (2008). Constituents of the sea cucumber Cucumaria okhotensis. Structures of okhotosides B1-B3 and cytotoxic activities of some glycosides from this species. J Nat Prod. 71: 351-356.

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