Cyclopamine is a steroidal alkaloid isolated from the corn lily that is an antagonist of the Sonic Hedgehog gene pathway with potential anticancer properties.
Cyclopamine is a teratogen that causes fatal birth defects. It can prevent the fetal brain from dividing into two lobes (holoprosencephaly) and cause the development of a single eye (cyclopia). Cyclopamine acts as a primary inhibitor of the so-called "hedgehog" signal-transduction pathway in cells. Cyclopamine inhibits the hedgehog signaling pathway (Hh) by influencing the balance between the active and inactive forms of the smoothened protein. This pathway, named for the ligand for the signal protein, is used by cells to help them react to external chemical signals. The pathway carries out important functions in embryonic development and when it goes awry, deformities can occur. Cyclopamine is useful in studying the role of Hh in normal development, and as a potential treatment for certain cancers in which Hh is over-expressed.
|Product Type:||Small Molecule|
|Format:||White to off-white crystals|
|Purity:||>99 % determined by HPLC|
|Solubility:||Soluble in DMSO (6 mg/mL), Water (1 mg/mL), and Ethanol (39 mg/mL)|
|Stability:||Stable as a solid over extended period at -20C.|
Cyclopamine HPLC Chromatogram.
Purification Notes: Cyclopamine is manufactured using near-critical and supercritical fluid phase extraction and segmentation chromatography.
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