Carboxyatractyloside dipotassium salt (C-ATR) is the dipotassium salt of a diterpenoid glycoside isolated from Cocklebur seeds. It is a highly selective and potent inhibitor of mitochondrial oxidative phosphorylation.
CAT is highly selective and potent inhibitor of mitochondrial oxidative phosphorylation. Specifically, it acts as a noncompetitive inhibitor of the adenine nucleotide translocator (ANT) in mitochondria with high affinity (Kd = 5-10 nM). ANT is the cytosolic side-specific mitochondrial ADP/ATP carrier protein. This results in stabilization of the c conformation of ANT, leading to permeability transition pore opening, loss of mitochondrial membrane potential and apoptosis. CAT stabilizes the nucleoside binding site of ANT on the cytoplasmic side of the inner membrane and blocks the exchange of matrix ATP and cytoplasmic ADP by forming a tight binding with the ADP/ATP carrier protein. All the chemical groups present in CAT, except the primary alcohol group of the ribose moiety, play a role in its toxicity by adding to the binding affinity of CAT to the carrier protein.
|Product Type:||Small Molecule|
|Format:||White crystalline solid|
|Purity:||>99 % determined by HPLC|
|Solubility:||Soluble in water|
|Stability:||Stable as a solid over extended period at -20C.|
|Storage:||-20C, avoid exposure to oxygen and direct sunlight|
Carboxyatractyloside dipotassium salt HPLC Chromatogram.
Purification Notes: Carboxyatractyloside is extracted from Xanthium strumarium seeds, purified using column chromatography, and then stabilized by crystallization as the dipotassium salt C-ATR.
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